Table 1 Baseline characteristics of cohorts
Parameter | Isolated RV dysfunction (n = 100) | RV/LV dysfunction (n = 114) | No RV dysfunction (n = 174) | p |
|---|---|---|---|---|
Age (years) | 65.6 (55.2–77.5) | 69.3 (55.3–77.4) | 64.7 (53.4–74.7) | 0.22 |
Male sex | 48 (48) | 59 (51.8) | 91 (52.3) | 0.78 |
Admitting location | 0.13 | |||
Emergency room | 53 (53) | 52 (45.6) | 86 (49.4) | |
Hospital floors | 21 (21) | 28 (24.6) | 55 (31.6) | |
Outside transfer | 26 (26) | 34 (29.8) | 33 (19) | |
Source of sepsis | 0.22 | |||
Respiratory | 27 (27) | 27 (23.7) | 27 (15.5) | |
Abdominal | 2 (2) | 3 (2.6) | 8 (4.6) | |
Genitourinary | 4 (4) | 6 (5.3) | 18 (10.3) | |
Skin/soft tissue | 3 (3) | 2 (1.8) | 9 (5.2) | |
Other/unknown | 38 (38) | 45 (39.5) | 69 (39.7) | |
Not available | 26 (26) | 31 (27.2) | 43 (24.7) | |
Body mass index (kg/m2) | 30.8 (24.6–36.7) | 28.6 (25–33.5) | 28.7 (24–33.7) | 0.29 |
Body surface area (m2) | 2.0 (1.8–2.3) | 1.9 (1.8–2.2) | 1.9 (1.8–2.2) | 0.27 |
Hypertension | 35 (35) | 51 (44.7) | 71 (40.8) | 0.35 |
Coronary artery disease | 10 (10) | 23 (20.2) | 23 (13.2) | 0.09 |
Prior myocardial infarction | 7 (7) | 13 (11.4) | 14 (8.1) | 0.48 |
Obstructive sleep apnea | 10 (10) | 19 (16.7) | 22 (12.6) | 0.34 |
Chronic lung disease | 24 (24) | 27 (23.7) | 41 (23.6) | 0.99 |
Charlson comorbidity index | 5 (3–7) | 6 (4–8) | 5 (3–8) | 0.40 |
APACHE-III score | 85.5 (68.3–110) | 84 (69–104) | 81 (66–105) | 0.54 |
SOFA score (day 1) | 9 (7–12) | 9 (7–11) | 8 (5–12) | 0.07 |
Septic shock | 80 (80) | 82 (71.9) | 119 (68.4) | 0.11 |
ARDS | 30 (30) | 36 (31.6) | 49 (28.2) | 0.82 |
Mild (n) | 6 | 10 | 15 | |
Moderate (n) | 18 | 18 | 22 | |
Severe (n) | 6 | 8 | 12 | |
Acute kidney injury | 62 (62) | 74 (64.9) | 110 (63.2) | 0.91 |
Admission troponin-T (ng/mL) | 0.06 (0.02–0.17) | 0.05 (0.03–0.15) | 0.06 (0.02–0.16) | 0.90 |
Highest lactate (mmol/L) | 2.8 (1.8–5.8) | 3.2 (1.8–5.5) | 3 (1.6–5.4) | 0.86 |
pH | 7.34 (7.26–7.39) | 7.33 (7.26–7.4) | 7.36 (7.29–7.42) | 0.03 |
pCO2 (mmHg) | 39 (33–45) | 36 (30–44) | 36 (31–42) | 0.04 |
PaO2/FiO2 ratio (mmHg) | 170 (127–287) | 196 (129–283) | 197 (111–288) | 0.87 |
Mechanical ventilation | 67 (67) | 58 (50.9) | 88 (50.6) | 0.03 |
PEEP (cm H2O) | 7.5 (5–10) | 8 (5–10) | 7.5 (5–10) | 0.34 |
PIP (cm H2O) | 25 (18–31) | 23 (17–29) | 21 (14–27) | 0.04 |
Plateau pressure (cm H2O) | 23 (17–30) | 20 (16–26) | 21 (15–25) | 0.17 |
Mean airway pressure (cm H2O) | 14 (10–19) | 14 (11–17) | 13 (10–17) | 0.39 |
Total norepinephrine (mg) | 18.5 (4.7–46.8) | 11.6 (3.8–33.5) | 14.3 (3.8–44.3) | 0.45 |
Crystalloid 24 h (L) | 4.2 (2.4–6.8) | 4.2 (2–6.2) | 4.2 (2.1–7.2) | 0.71 |