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Table 1 Demographic, clinical and biochemical parameters in 198 APAP-ALF patients by outcome

From: The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

  APAP alive day 21 (n = 99) APAP dead day 21 (n = 99) p value
N Number (%) or median (IQR) N Number (%) or median (IQR)
Age 99 35 (28–43) 99 40 (30–48) 0.084
Sex (female) 99 75 (76%) 99 72 (73%) 0.63
Race      0.23
 White 99 83 (84%) 99 79 (80%)  
 African-American 99 8 (8%) 99 15 (15%)  
 Other 99 8 (8%) 99 5 (5%)  
Organ support (days 1–7)      
 Mechanical ventilation 99 64 (65%) 99 93 (93%) < 0.0001
 Vasopressors 99 12 (12%) 99 69 (70%) < 0.0001
 Renal replacement therapy 99 27 (27%) 99 45 (45%) 0.0078
KCC 87 7 (7%) 87 16 (16%) 0.13
Coma grade 3/4 (worst days 1–7) 99 61 (62%) 98 91 (93%) < 0.0001
ICP-directed therapies (days 1–7)      
 ICP monitor 99 12 (12%) 99 21 (21%) 0.086
 Mannitol 99 22 (22%) 99 46 (46%) 0.0003
 Hypertonic saline 99 11 (11%) 99 14 (14%) 0.52
 Barbiturates 99 9 (9%) 99 20 (20%) 0.043
 Hypothermia 99 17 (17%) 99 14 (14%) 0.56
 Sedatives 99 70 (71%) 99 88 (89%) 0.0014
Blood products (days 1–7)      
 Red blood cells 99 34 (34%) 99 50 (51%) 0.021
 Fresh-frozen plasma 99 50 (51%) 99 76 (77%) 0.0001
 Recombinant VIIA 99 3 (3%) 99 5 (5%) 0.72
 Platelets 99 17 (17%) 99 36 (36%) 0.0023
ICU complications (days 1–7)      
 Seizures 99 3 (3%) 99 21 (21%) < 0.0001
 Arrhythmias 99 25 (25%) 99 38 (38%) 0.047
 GI bleeding 99 8 (8%) 99 19 (19%) 0.037
 ARDS 99 0 (0%) 99 3 (3%) 0.25
 CT (cerebral edema) 55 7 (13%) 72 32 (44%) < 0.001
 Abnormal CXR 99 88 (89%) 99 83 (84%) 0.30
 Bacteremia/blood stream infection 99 7 (7%) 99 10 (10%) 0.61
Cause of death      
 Multiorgan failure    99 52 (53%)  
 Cerebral edema    99 38 (38%)  
 Unknown    99 9 (9%)  
  1. N frequency, IQR interquartile range, ARDS acute respiratory syndrome, CT computed tomography, CXR chest x-ray