Table 1 Hemodynamic parameters of septic shock patients treated with prior BB therapy
From: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress
Baseline characteristics | Total (n = 938) | ß-blockers (n = 230) | no ß-blockers (n = 708) | P |
|---|---|---|---|---|
Age, mean (SD) | 69 (58–79) | 72.9 (61.5–80) | 66.9 (56–78) | <.001 |
Male, n (%) | 598 (63.8%) | 152 (66.1%) | 446 (63%) | 0.43 |
Prior congestive heart Failure, n (%) | 210 (22.4%) | 81 (35%) | 129 (18.2%) | <.001 |
Cirrhosis, n (%) | 99 (10.6%) | 36 (15.7%) | 63 (8.9%) | 0.004 |
Diabetes, n (%) | 172 (18.3%) | 51 (22.2%) | 121 (17.1%) | 0.077 |
Obesity, n (%) | 88 (9.4%) | 23 (10%) | 65 (9.2%) | 0.696 |
Immunosuppression, n (%) | 355 (37.8%) | 84 (36.5%) | 271 (38.3%) | 0.696 |
Chronic obstructive pulmonary disease, n (%) | 149 (15.9%) | 33 (14.3%) | 116 (16.4%) | 0.533 |
Prior kidney failure, n (%) | 127 (13.5%) | 42 (18.3%) | 85 (12%) | 0.019 |
SOFA J0, mean (SD) | 9 (6–13) | 9 (6–12) | 9 (6–13) | 0.242 |
IGS2, mean (SD) | 67 (52–84) | 68 (54–85) | 67 (51–84) | 0.245 |
Heart rate on admission, mean (SD) | 103.5 (87–120) | 81.5 (82–111) | 107 (89–122) | <.001 |
Creatinin, mean (SD) | 142.5 (89–222) | 165.5 (108–245) | 135.5 (82–208) | <.000 |
Bilirubin, mean (SD) | 13 (8–27) | 14 (8.75–28.25) | 12 (8–27) | 0.065 |
TP, mean (SD) | 59 (44–72) | 56.5 (41–70) | 60 (45–73) | 0.101 |
Leucocyte count, mean (SD) | 12 (5.4–20) | 13.4 (6.0–19.8) | 11.8 (5.0–20.6) | 0.576 |
Arterial pH, mean (SD) | 7.34 (7.24–7.42) | 7.35 (7.25–7.42) | 7.34 (7.23–7.42) | 0.354 |
Arterial lactate, mean (SD) | 1.8 (0.9–3.9) | 1.75 (0.9–3.4) | 1.8 (0.8–4.0) | 0.974 |
Hemoglobin, mean (SD) | 11 (9.1–12.5) | 10.9 (9.3–12.4) | 10.9 (9.1–12.5) | 0.618 |
CaO2, mean (IC) | 1357 (1146–1588) | 1385 (1159–1598) | 1355 (1139–1587) | 0.347 |
Outcome | ||||
Norepinephrine dose on day 1, mean (IC) | 22.58 (5.18–59) | 23.2 (5.1–57.0) | 22.4 (5.2–60.5) | 0.95 |
Use of positive inotropic drugs, n (%) | 51 (5.4%) | 9 (3.9%) | 42 (5.9%) | 0.248 |
Epinephrine use, n (%) | 75 (8.0%) | 19 (8.3%) | 56 (8.1%) | 0.89 |
Fluid requirement on day 1, mean (IC) | 3250 (1900–4900) | 2950 (1500–4500) | 3400 (2000–5000) | 0.001 |
Fluid balance on day 1, mean (IC) | 2100 (700–3950) | 1790 (500–3430) | 2200 (800–4070) | 0.027 |
Protidemia at 24h, mean (IC) | 58 (50–66) | 59 (51.7–68) | 57 (50–66) | 0.015 |
Urine Output on day 1, mean (IC) | 870 (350–1430) | 835 (352–1400) | 900 (340–1600) | 0.442 |
Mechanical ventilation, n (%) | 789 (84.1%) | 188 (81.7%) | 601 (84.9%) | 0.112 |
Days of mechanical Ventilation, mean (SD) | 5 (2–10.5) | 4 (2–9) | 5.5 (2–11) | 0.055 |
In-hospital mortality, n (%) | 344 (36.7%) | 82 (35.7%) | 262 (37%) | 0.753 |