Table 1 Baseline characteristics for ALL and matched-INDICATED populations by treatment
Baseline characteristicsa | ALL patients | Matched-INDICATED | ||
|---|---|---|---|---|
DrotAA (n = 784) | NonDrotAA (n = 18,138) | DrotAA (n = 692) | NonDrotAA (n = 1935) | |
Age (Mean) | 58.4 | 60.4 | 59.0 | 59.1 |
SD | 16.1 | 16.9 | 15.4 | 9.2 |
P valueb | 0.001 | 0.69 | ||
Male (%) | 59.7 | 59.9 | 60.1 | 61.2 |
P value | 0.93 | 0.65 | ||
APACHE II (mean) | 26.1 | 21.1 | 25.8 | 25.5 |
SD | 8.2 | 7.7 | 7.9 | 4.7 |
P value | < 0.0001 | 0.02 | ||
SAPS II (mean) | 58.1 | 47.8 | 59.1 | 58.5 |
SD | 19.2 | 19.1 | 18.8 | 10.9 |
P value | < 0.0001 | 0.77 | ||
Origin of sepsis (%) | ||||
Nosocomial | 8.4 | 4.7 | 7.2 | 12.3 |
Community acquired | 38.6 | 14.3 | 39.7 | 34.7 |
Unknown | 52.9 | 81.0 | 53.0 | 53.0 |
P value | 0.003 | < 0.0001 | ||
Anatomic site of primary infection (%) | ||||
Lung | 51.5 | 23.4 | 52.9 | 46.8 |
Abdomen | 12.2 | 6.9 | 13.2 | 12.7 |
CNS | 1.3 | 0.6 | 0.9 | 0.7 |
Blood | 3.4 | 2.0 | 3.0 | 3.5 |
Urinary tract | 4.1 | 2.7 | 3.8 | 3.3 |
Unknown | 22.1 | 60.2 | 21.1 | 29.0 |
Other | 5.4 | 4.2 | 5.2 | 4.1 |
P value | 0.0004 | 0.55 | ||
Use of vasopressors (%) | ||||
Yes | 91.2 | 54.7 | 91.8 | 81.2 |
No | 8.3 | 39.2 | 7.8 | 17.8 |
Unknown | 0.5 | 6.1 | 0.4 | 1.0 |
P value | < 0.0001 | < 0.0001 | ||
Mechanical ventilation (%) | ||||
Yes | 76.3 | 72.3 | 75.7 | 76.4 |
No | 6.4 | 19.5 | 6.2 | 5.2 |
Unknown | 17.3 | 8.2 | 18.1 | 18.4 |
P value | < 0.0001 | 0.08 | ||
Number of organ systems with dysfunction (%) | ||||
0 | 1.4 | 9.9 | 0.0 | 0.0 |
1 | 2.2 | 23.8 | 0.1 | 0.8 |
2 | 20.7 | 30.8 | 21.0 | 22.0 |
3 | 33.0 | 19.4 | 35.1 | 34.0 |
4 | 24.9 | 11.3 | 26.3 | 29.4 |
5 | 13.6 | 4.1 | 13.9 | 11.7 |
6 | 4.2 | 0.7 | 3.6 | 2.2 |
P value | < 0.0001 | 0.82 | ||
Cardiovascular dysfunction (%) | ||||
Yes | 96.0 | 66.9 | 98.7 | 98.3 |
No | 2.4 | 30.2 | 1.0 | 1.0 |
Unknown | 1.5 | 2.9 | 0.3 | 0.7 |
P value | < 0.0001 | 0.36 | ||
Pulmonary dysfunction (%) | ||||
Yes | 92.6 | 69.5 | 95.4 | 95.3 |
No | 5.1 | 18.8 | 3.9 | 3.4 |
Unknown | 2.3 | 11.7 | 0.7 | 1.3 |
P value | < 0.0001 | 0.34 | ||
CNS dysfunction (%) | ||||
Yes | 28.4 | 21.0 | 27.7 | 31.4 |
No | 33.2 | 34.5 | 33.8 | 30.9 |
Unknown | 38.4 | 44.5 | 38.4 | 37.7 |
P value | 0.0003 | 0.01 | ||
Coagulation dysfunction (%) | ||||
Yes | 31.4 | 14.0 | 31.8 | 25.0 |
No | 65.4 | 68.7 | 66.3 | 72.6 |
Unknown | 3.2 | 17.3 | 1.9 | 2.4 |
P value | < 0.0001 | < 0.0001 | ||
Renal dysfunction (%) | ||||
Yes | 63.3 | 29.4 | 65.6 | 61.7 |
No | 33.9 | 54.1 | 32.4 | 36.6 |
Unknown | 2.8 | 16.6 | 2.0 | 1.7 |
P value | < 0.0001 | < 0.01 | ||
Hepatic dysfunction (%) | ||||
Yes | 23.9 | 13.0 | 24.4 | 23.8 |
No | 66.8 | 66.7 | 67.6 | 68.5 |
Unknown | 9.3 | 20.3 | 7.9 | 7.7 |
P value | < 0.0001 | 0.71 | ||