Table 1 Summary of candidate MSC-VEC-miRNAs Regulation in vascular endothelial cells
MiRNAs | Function on angiogenic process | Gene targets | Adjusting direction |
|---|---|---|---|
miR-15a | Inhibits angiogenesis through direct targeting of VEGF and FGF | FGF2, FGFR1, VEGF, VEGFR2 | – |
miR-16 | Inhibits tumor angiogenesis and EC-mediated angiogenesis in vitro and in vivo | FGF2, FGFR1, VEGF, VEGFR2 | – |
miR-21 | Induces tumor angiogenesis in vitro | PTEN | + |
miR-24 | Decreases endothelial cell proliferation | Sp1 | – |
miR-26a | Prevents endothelial cell apoptosis | TRPC6 | + |
miR-27a | Promotes EC angiogenesis in vitro | SEMA6A, Spry2, Dll4 | + |
miR-27b | Promotes EC angiogenesis in vitro | SEMA6A, Spry2, Dll4 | + |
miR-126 | Promotes EC angiogenesis in vitro and in vivo | Spred-1, PIK3R2, VCAM-1 | + |
miR-150 | Restores vascular barrier function | Ang2 | + |
miR-146a | Promotes senescence of endothelial cells | NOX4 | – |
miR-155 | Promotes tumor angiogenesis | VHL | + |
miR-221 | Inhibits EC-mediated angiogenesis in vitro | c-kit, eNOS | – |
miR-223 | Prevents endothelial cell proliferation | β1 integrin, IGF-1R | – |
miR-320 | Inhibits diabetic angiogenesis in vitro | IGF-1 | – |