Duration of acute kidney injury in critically ill patients

Annals of Intensive Care

Table 3 Factors associated with resolving AKI

n = 236	Univariate Cox regression (hazard ratio)		p value	Multivariate Cox regression (hazard ratio)		p value
n = 236	HR	(95% CI)	p value	HR	(95% CI)	p value
Age, per 10 year increase	0.94	0.86–1.03	0.19
Female gender	0.85	0.61–1.17	0.31
White race	1.03	0.70–1.51	0.88
Hispanic or Latino ethnic group	1.50	0.98–2.30	0.06
BMI	1.00	0.98–1.02	0.88
Diabetes mellitus	0.91	0.61–1.34	0.63
History of hypertension	0.91	0.65–1.26	0.55
Platelet count			< 0.001			0.27
> 150 × 10⁹/L	1			1
< 150 × 10⁹/L	0.54	0.38–0.78		0.80	0.53–1.19
Urine output			< 0.0001			0.01
> 0.5 mL/kg/h	1			1
< 0.5 mL/kg/h	0.31	0.20–0.47		0.53	0.32–0.87
PaO₂/FiO₂ ratio			< 0.0001			0.001
> 200	1			1
< 200	0.52	0.38–0.71		0.59	0.44–0.81
Creatinine mg/dl, per unit increase	0.59	0.48–0.74	< 0.0001	0.71	0.57–0.89	0.003
Systolic BP, per 10 mm Hg increase	1.15	1.05–1.25	0.002	1.09	0.99–1.20	0.07
Vasopressor use	0.46	0.32–0.67	< 0.0001	0.91	0.59–1.41	0.68

Factors associated with resolving AKI, defined as an AKI duration of less than 7 days, analyzed by the proportional subdistribution hazards model proposed by Fine and Gray, with death as a competing risk. Two patients were excluded from the original population (n = 238) due to missing values
AKI acute kidney injury, BMI body mass index, BP blood pressure, PaO₂/FiO₂ ratio partial pressure arterial oxygen/fraction of inspired oxygen