Table 1 Baseline characteristics
Parameter | Propensity score-matched controls (n = 178) | Liver cirrhosis (n = 178) | p value |
|---|---|---|---|
Age, years (IQR) | 65 (55–75) | 55 (48–62) | < 0.01 |
Male gender, n (%) | 79 (44%) | 82 (46%) | 0.837 |
SOFA score (IQR) | 12 (8–16) | 13 (10–16) | 0.084 |
SAPS II score (IQR) | 59 (44–72) | 62 (44–79 | 0.101 |
CLIF-SOFA score (IQR) | – | 14 (11–16) | |
ACLF grade | |||
No ACLF, n (%) | 21 (12%) | ||
Grade I, n (%) | – | 27 (15%) | |
Grade II, n (%) | – | 45 (25%) | |
Grade III, n (%) | – | 85 (48%) | |
CLIF-C ACLF score (IQR) | – | 56.5 (48.8–63.3) | |
MELD score (IQR) | – | 26 (20–35) | |
Child–Pugh score (IQR) | – | 11 (10–13) | |
Acute kidney injury, n (%) | 133 (75%) | 138 (78%) | 0.575 |
Vasopressor support, n (%) | 154 (87%) | 158 (89%) | 0.596 |
Mechanical ventilation, n (%) | 116 (65%) | 101 (57%) | 0.120 |
Laboratory parameters | |||
AST, U/l (IQR) | 51 (30–116) | 94 (54–204) | < 0.01 |
ALT, U/l (IQR) | 32 (19–71) | 43 (24–85) | 0.096 |
Bilirubin, mg/dl (IQR) | 1.0 (0.6–1.9) | 5.4 (2.9–14.4) | < 0.01 |
INR (IQR) | 1.2 (1.1–1.4) | 1.8 (1.5–2.5) | < 0.01 |
Creatinine, mg/dl (IQR) | 1.8 (1.2–2.7) | 1.8 (1.1–3.1) | 0.851 |
Outcome | |||
28-Day mortality, n (%) | 54 (30%) | 105 (59%) | < 0.01 |