Fig. 4

Schematic diagram of the effects of midazolam. Venous return curve and cardiac output curve constructed from the average values of central venous pressure, mean systemic filling pressure and cardiac output after resuscitation and midazolam infusion. The dots are the values derived from Table 1. (a) The working point of the circulation during T1; (b) the volume effect of generalized vasodilatation on CO by midazolam; (c) an additional effect of midazolam on resistance for venous return; (d) the volume effect of generalized vasodilatation on CO by fluid administration after midazolam. Cardiac output; CVP central venous pressure