Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome

Annals of Intensive Care

Table 1 Hemodynamic parameters and temperatures throughout protocol in rabbits presenting experimental acute respiratory distress syndrome and treated by gaseous lung protective ventilation (LPV) or total liquid ventilation (TLV), respectively

Parameters and groups	Baseline	Conventional ventilation		LPV or TLV
Parameters and groups	Baseline	15 min	90 min	10 min	60 min	120 min
Esophageal temperature (°C)
LPV	38.7 ± 0.5	38.1 ± 0.6	38.2 ± 0.4	38.2 ± 0.4	38.6 ± 0.4	38.6 ± 0.4
TLV	38.5 ± 0.8	38.0 ± 0.8	38.8 ± 0.5	32.6 ± 0.6*	33.1 ± 0.3*	33.2 ± 0.2*
Rectal temperature (°C)
LPV	38.7 ± 0.5	38.1 ± 0.6	38.2 ± 0.4	38.3 ± 0.3	38.4 ± 0.3	38.4 ± 0.4
TLV	38.7 ± 0.5	37.8 ± 0.9	39.1 ± 0.4	34.8 ± 0.5*	33.0 ± 0.2*	33.0 ± 0.1*
Heart rate (beats/min)
LPV	257 ± 18	233 ± 16	246 ± 17	255 ± 17	248 ± 15	253 ± 7
TLV	242 ± 17	242 ± 17	262 ± 15	171 ± 6*	172 ± 6*	165 ± 7*
Mean arterial blood pressure (mmHg)
LPV	75 ± 7	74 ± 6	65 ± 6	67 ± 5	61 ± 4	56 ± 8
TLV	69 ± 5	73 ± 3	65 ± 5	69 ± 6	82 ± 6*	74 ± 9*
Lung compliance (ml/kg/cmH₂O)
LPV	0.99 ± 0.11	0.59 ± 0.10	0.56 ± 0.09	0.78 ± 0.16	0.78 ± 0.16	0.65 ± 0.10
TLV	1.09 ± 0.18	0.61 ± 0.07	0.63 ± 0.09	0.74 ± 0.09	0.71 ± 0.07	0.67 ± 0.06

Statistical comparisons were only made for group effect but not among time points
n = 8 in each LPV and TLV group
*p < 0.05 versus LPV