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Table 1 Demographics and clinical data of patients with appropriate and non-appropriate procalcitonin (PCT) measurement series

From: Adherence to a procalcitonin-guided antibiotic treatment protocol in patients with severe sepsis and septic shock

  Patients with appropriate PCT series (n = 42) Patients with non-appropriate PCT series (n = 25) p value
Age, years (median [IQR]) 68 [59–76] 76 [68–79] 0.172
SAPS II score (median [IQR]) 40 [29–51] 38 [32–47] 0.807
Male gender (% [95% CI]) 59.5 [43.3–74.4] 60.0 [38.7–78.9] 0.999
ICU mortality (% [95% CI]) 40.5 [26–57] 32.0 [14.9–53.5] 0.604
Ventilation hours (median [IQR]) 423 [68–840] 102 [8–335] 0.012
ICU LOS, days (median [IQR]) 17 [5–41] 11 [4–21] 0.264
Hospital LOS, days (median [IQR]) 42 [25–73] 39 [25–54] 0.351
SOFA score max (median [IQR]) 11 [9–13] 9 [8–11] 0.112
Length of antibiotic treatment, days (median [IQR]) 10 [7–13] 5 [4–6] < 0.001
Antibiotic use density, DDD (median [IQR]) 11 [9–23] 6 [4–9] < 0.001
Initial PCT value, ng/mL (median [IQR]) 9.15 [3.1–32.4] 1.55 [0.9–4.6] 0.001
Peak PCT value, ng/mL (median [IQR]) 30.2 [7.1–60.7] 3.8 [1.6–10.3] < 0.001
  % [95% CI] (n) % [95% CI] (n)
Cause of infection
Abdominal sepsis 52.4 [36.4–67.9] (22) 44.0 [24.4–65.1] (11)
Bloodstream infection 0 4.0 [0.1–20.3] (1)
Pleural empyema 9.5 [2.6–22.6] (4) 0
Pneumonia 19.0 [8.6–34.1] (8) 32.0 [14.9–53.5] (8)
Prosthetic infection 0 8.0 [1.0–26.0] (2)
Urogenital sepsis 9.5 [2.6–22.6] (4) 8.0 [1.0–26.0] (2)
Soft tissue infection 2.4 [0.6–12.6] (1) 4.0 [0.1–20.3] (1)
Unknown 7.1 [1–19] (3) 0
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