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Table 3 Univariable and multivariable analyses of factors associated with major vascular complications (severe limb ischemia and cannulation site bleeding)

From: Vascular complications in adult postcardiotomy cardiogenic shock patients receiving venoarterial extracorporeal membrane oxygenation

Factor Univariable analysis OR [95% CI], p value Multivariable analysis OR [95% CI], p value
Severe limb ischemia
Peripheral artery disease 0.73 [0.37–1.46] 0.378  
Hypertension 0.79 [0.47–1.31] 0.356  
Hypercholesterolemia 0.84 [0.33–2.13] 0.718  
Smoking 0.75 [0.45–1.25] 0.276  
Obesity 3.47 [1.20–10.03] 0.005 2.65 [1.26–5.56] 0.010
Coronary artery disease 2.47 [1.19–5.14] 0.022  
Diabetes 0.86 [0.68–3.14] 0.326  
Combined with IABP 2.97 [1.33–6.67] 0.018 2.49 [1.19–2.65] 0.025
ECPR 0.83 [0.43–1.63] 0.597  
Lactate at ECMO initiation 1.07 [0.98–1.14] 0.052  
Peak lactate during ECMO 1.10 [1.03–1.16] 0.002  
SOFA score at ECMO initiation 2.09 [1.60–2.23] < 0.001  
SOFA score at 24 h post-ECMO 1.67 [1.41–1.98] < 0.001 1.43 [1.08–1.86] 0.010
Cannulation site bleeding
Hemostasis disorders during ECMO 7.21 [2.28–22.77] < 0.001 6.11 [1.88–19.87] < 0.001
  1. CNS central nervous system complications, CRRT continuous renal replacement treatment, DIC disseminated intravascular coagulation, ECMO extracorporeal membrane oxygenation, ECPR extracorporeal cardiopulmonary resuscitation, IABP intra-aortic balloon pump, SOFA sequential organ failure assessment
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