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Annals of Intensive Care

Table 3 Pmcf and pharmacodynamics

From: Estimating mean circulatory filling pressure in clinical practice: a systematic review comparing three bedside methods in the critically ill

References

Method

n

Situation A

Situation B

p value*

Situation C

p value#

Persichini et al. [27]

 

16

NE 0.30

NE 0.19

   
   

Range 0.10–1.40

Range 0.08–1.15

   
 

Pmcf hold (in mmHg)

 

33 (12)

26 (10)

0.003

  

Maas et al. [25]

 

16

Baseline 1

NE increase of 0.04 (0.02)

 

Baseline 2

 
   

NE 0.04 (0.03)

  

NE 0.04 (0.03)

 
 

Pmcf hold (in mmHg)

 

21.4 (6.1)

27.6 (7.4)

< 0.001

22.0 (5.3)

 

de Wit et al. [24]

 

17

Propofol low

Propofol medium

 

Propofol high

 
   

Cb 3.0 (0.90) μg/mL

Cb 4.5 (1.0) μg/mL

 

Cb 6.5 (1.2) μg/mL

 
 

Pmcf hold (in mmHg)

 

27.9 (5.4)

24.6 (4.9)

0.01

21.4 (4.2)

< 0.001

Helmerhorst et al. [26]

 

22

FiO2 21–30%

FiO2 90%

   
 

Pmcf hold (in mmHg)

 

20.8 (3.5)

23.1 (4.0)

< 0.001

  
  1. NE norepinephrine dose in μg/kg/min presented as mean with range or mean with standard deviation. Pmcf values are presented as mean with standard deviation. Cb target blood concentration of propofol in μg/mL. Pmcf hold values presented in mmHg. FiO 2 fractional oxygen concentration
  2. * p value, p value for situation A compared to B
  3. #p value, p value for situation A compared to C
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