Table 1 Prospective studies with MAP titration and peripheral (microcirculatory) or targeted tissue/organ perfusion assessment in septic shock
Authors [ref.] | No. of patients (n) | Design of MAP titration in mmHg (time at each step, min) | Main results |
|---|---|---|---|
Ledoux et al. [25] | 10 | 65, 75, 85 mmHg (105) | CI ↑ Arterial lactates, gastric intra-mucosal-arterial PCO2 difference, skin microcirculatory blood flow (skin capillary blood flow and red blood cell velocity), urine output: ns |
Bourgoin et al. [26] | 2 × 14 | MAP 65 versus 85 mmHg (240) comparison of two groups | CI ↑ Arterial lactates, VO2, and renal function: ns |
Deruddre et al. [27] | 11 | 65, 75, 85 mmHg (120) | 65–75 mmHg: urine output ↑, RRI ↓ 75–85 mmHg: urine output, RRI: ns Creatinine clearance: ns |
Jhanji et al. [28] | 16 | 60, 70, 80, 90 mmHg (45) | DO2, cutaneous PtO2, cutaneous microvascular red blood cell flux (laser Doppler flowmetry) ↑ Sublingual capillary MFI (SDF): ns |
Dubin et al. [29] | 20 | 65, 75, 85 mmHg (30) | CI, systemic vascular resistance, left and right ventricular stroke work indexes ↑ Arterial lactates, DO2, VO2, gastric intra-mucosal-arterial PCO2 difference, sublingual capillary MFI and percent of perfused capillaries (SDF imaging): ns |
Thooft et al. [30] | 13 | 65, 75, 85 mmHg (30) | CI, SvO2, StO2, sublingual perfused vessel density and MFI (SDF imaging) ↑ VO2: ns Arterial lactates ↓ |