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Annals of Intensive Care

Table 4 Significant correlations in Group B between circadian variables, severity of illness scores and different outcomes of interest (ICU & hospital LOS and hospital mortality)

From: Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study

  Entry Septic shock Exit (recovery phase)
APACHE II SOFA SAPS II ICU LOS Hospital LOS Hospital mortality APACHE II SOFA SAPS II ICU LOS Hospital LOS Hospital mortality APACHE II SOFA SAPS II ICU LOS Hospital LOS Hospital mortality
aMT6s mean         0.6   0.5 0.5        
aMT6s ampl        – 0.5 –          
aMT6s peak time        0.9*   0.9* 0.6 0.6 0.7*       
Cortisolmean 0.5        − 0.8 0.5 − 0.9* − 0.8* 0.6*    − 0.5    
Cortisol ampl 0.5    0.5 0.5    − 0.6   − 0.6* − 0.7* 0.6*    − 0.6    
Cortisol peak time     0.5     − 0.95   − 0.9* − 0.7* 0.6* 0.5 0.6     
  1. All correlations were found statistically significant with a p value < 0.05
  2. ampl amplitude (difference between peak and mean values), LOS length of stay
  3. * Correlations who passed the Bonferroni correction test with a p value < 0.004 (p corrected = 0.05/12)
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