Proportional modes versus pressure support ventilation: a systematic review and meta-analysis

Annals of Intensive Care

Table 3 Results of secondary outcomes

Outcomes	No. of trials (PAV/NAVA)	Total sample size	Summary estimates (95% confidence intervals)	Q	df	I² (%)
Weaning time from randomization (day)	PAV 2 [24, 28] NAVA 1 [25]	220	WMD − 1.21 (− 4.32, 1.91)	3.66	2	45.3
Switching again to a controlled mode	PAV 1 [24] NAVA 1 [25]	168	RR 1.00 (0.77, 1.31)	0.30	1	0.0
Length of ICU (day)	PAV 4 [22,23,24, 28] NAVA 2 [25, 27]	528	WMD − 1.41 (− 3.90, 1.09)	12.43	5	59.8
Length of hospital stay (day)	PAV 3 [23, 24, 28] NAVA 2 [25, 27]	320	WMD − 0.26 (− 3.90, 3.37)	7.73	4	48.2
Tracheostomy	PAV 2 [24, 28]	98	RR 0.65 (0.31, 1.37)	0.09	1	0.0
Reintubation	PAV 3 [23, 24, 28]	158	RR 0.39 (0.17, 0.90)	0.39	2	0.0
Use of NIV after extubation	PAV 1 [24] NAVA 1 [25]	178	RR 0.64 (0.47, 0.89)	0.13	1	0.0

RR risk ratio, WMD weighted mean difference, ICU intensive care unit, PAV proportional assisted ventilation, NAVA neurally adjusted ventilatory assist