Table 4 Univariable and multivariable analyses of factors associated with intracranial bleeding on VA-ECMO
From: Ischemic and hemorrhagic brain injury during venoarterial-extracorporeal membrane oxygenation
Factor | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
OR [95% CI] | P value | OR [95% CI] | P value | |
Age > 53 years | 0.6 [0.2–1.5] | 0.3 | ||
Female sex | 3 [1.2–7.3] | 0.02 | 2.9 [1.1–7.5] | 0.03 |
Previous history of stroke | 3 [0.9-10.92] | 0.1 | ||
SAPS II at ICU admission ≥ 72 | 1.2 [0.5–2.8] | 0.8 | ||
Renal replacement therapy | 2 [0.6–7] | 0.3 | ||
Intra-aortic balloon pump | 0.5 [0.2–1.5] | 0.3 | ||
Central VA-ECMO | 5.0 [2.0–12.2] | 0.0007 | 3.8 [1.1–10.2] | 0.008 |
Cardiac surgery | 0.9 [0.4–2.3] | 1 | ||
Biology at ECMO onset | ||||
Lactate > 6 mmol/L | 2.7 [0.9–7.6] | 0.06 | ||
pH < 7.32 | 1.0 [0.4–2.6] | 1 | ||
Platelets < 100 giga/L | 4.3 [1.7–11.3] | 0.003 | 3.7 [1.4–9.7] | 0.009 |
Bilirubin > 33 µmol/L | 1.8 [0.7–4.8] | 0.3 | ||
Fibrinogen < 1.5 g/L | 1.7 [0.5–6.2] | 0.4 | ||
Prothrombin time < 30%a | 2.7 [1.0–7.7] | 0.07 | ||
aPTT, patient/normal-value ratio > 3 | 2.3 [0.8–6.7] | 0.2 | ||
Hemostasis disorders on ECMOb | ||||
Platelets < 100 × giga/L | 1.2 [0.4–4.3] | 1 | ||
Prothrombin time < 30%a | 2.0 [0.8–5.0] | 0.1 | ||
Fibrinogen < 1.5 g/L | 1.9 [0.7–4.9] | 0.2 | ||
aPTT, patient/normal-value ratio > 3 | 1.1 [0.4–3.1] | 0.8 | ||