Fig. 2From: Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?Frequency of immune-related adverse events. a Toxicity related to anti-PD-1/PDL-1i; b toxicity related to CTLA-4i. The size of the circles reflects the incidence of toxicity: blue, toxicity of any grade; red, grade III/IV toxicity. None of the circles describe toxicity related to CTLA-4i associated with PD-1/PDL-1i inhibitors (the incidence of combined treatments is higher than the toxicity of each inhibitor). Incidence data from [8] and [47] Back to article page