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Fig. 4 | Annals of Intensive Care

Fig. 4

From: Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?

Fig. 4

References: [3,4,5, 13, 16,17,18, 24, 33, 34, 40, 60, 71, 75, 88,89,90,91,92,93,94,95]

Frequencies of grade III and IV IrAEIrAE in studies. Meta-analysis of randomized control trials including CTLA4i (upper plot), CTLA4i + PD1i/PDL1i (middle plot) or PD1i/PDL1i (lower plot). The forest plots represent the frequencies of IrAEIrAE organ by organ. a Severe liver IrAE; b severe neurological IrAE.

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