Skip to main content

Table 2 Laboratory parameters, ELISA and LC–MS measurements

From: Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Parameter Baseline Pre Onset 24 h 48 h 7d
Healthy Surgical Surgical Sepsis Surgical Sepsis Surgical Sepsis Surgical Sepsis
Leucocytes (1/nL) 6.16 (5.11–7.58) 6.14 (4.53–8.42) 12.18 (9.71–14.89) 19.21 (7.74–27.31) 11.71 (8.96–13.95) 19.86 (12.51–33.36) 9.51 (7.64–12.00) 19.95 (12.31–30.84) 10.35 (7.65–13.30) 14.21 (9.52–20.05)
  0.039* < 0.001*** < 0.001*** 0.115
CRP (mg/L) 2.00 (2.00–2.85) 2.00 (2.00–6.65) 2.70 (2.00–9.85) 218.90 (144.05–269.08) 133.70 (90.63–157.40) 263.25 (159.75–320.30) 143.30 (112.10–162.30) 179.00 (116.25–293.05) 68.30 (29.45–130.70) 120.90 (72.30–158.10)
  < 0.001*** < 0.001*** 0.041* 0.150
PCT (ng/mL) 0.05 (0.05–0.05) 0.05 (0.05–0.07) 0.09 (0.05–0.19) 17.54 (1.68–48.18) 1.08 (0.43–2.18) 11.96 (3.27–35.07) 0.78 (0.36–1.49) 8.99 (1.77–28.69) 0.11 (0.10–0.81) 1.03 (0.47–1.45)
  < 0.001*** < 0.001*** < 0.001*** 0.008**
TAT (ng/mL) 3.30 (2.40–6.60) 9.90 (6.33–11.35) 9.90 (6.68–11.70) 12.85 (11.16–14.83) 9.23 (5.91–13.38) 12.53 (10.84–15.28) 10.30 (5.35–12.95) 13.73 (11.28–17.48) 10.90 (6.83–13.40) 14.70 (11.63–18.45)
  < 0.001*** 0.003** 0.001** 0.021*
D-dimer (mg/L) 0.37 (0.26–0.57) 0.48 (0.34–0.85) 3.55 (1.85–4.13) 7.59 (4.54–13.85) 3.50 (2.23–4.10) 6.94 (4.16–12.27) 2.41 (1.85–3.38) 6.77 (4.14–11.87) 4.68 (3.78–5.84) 5.47 (4.32–7.43)
  < 0.001*** 0.001** < 0.001*** 0.412
PT index (%) 109.5 (104.70–117.30) 94.00 (88.30–100) 91.00 (78.20–98.75) 68.75 (46.85–76.35) 70.05 (61.30–84.40) 65.80 (53.63–85.65) 94.00 (85.70–100.90) 81.00 (65.75–92.13) 96.80 (89.85–113.80) 81.90 (71.40–91.60)
  < 0.001*** 0.304 0.008** 0.004**
aPTT (s) 24.00 (22.65–25.90) 23.80 (22.65–25.90) 22.00 (20.60–23.95) 32.90 (28.45–37.80) 26.35 (24.53–28.48) 37.80 (31.33–44.53) 26.30 (23.80–28.00) 33.90 (27.65–40.55) 24.50 (21.50–27.05) 27.90 (26.10–35.00)
  < 0.001*** < 0.001*** < 0.001*** 0.009**
Platelet count (1/nL) 249.00 (209.50–275.75) 183.00 (167.50–232.50) 200.00 (172.00–248.50) 181.50 (101.50–229.50) 156.00 (133.00–191.80) 152.5 (59.30–253.00) 156.00 (137.00–197.00) 142.00 (68.00–255.00) 264.00 (246.00–315.50) 258.00 (204.50–377.50)
  0.157 0.408 0.252 0.755
PG F1α (pg/mL) 22.9 (20.7–48.0) 82.0 (45.8–121.4) 54.9 (28.3–71.2) 278.3 (50.3–591.3) 10.1 (5.2–45.5) 431.0 (117.9–972.2) 7.7 (2.0–27.9) 283.9 (97.7–1165.8) 7.5 (1.2–59.1) 345.2 (48.4–689.0)
  < 0.001*** < 0.001*** < 0.001*** 0.016*
11d-TX B2 (pg/mL) 45.6 (36.9–73.4) 8.3 (5.1–19.8) 9.5 (5.6–14.6) 18.7 (9.6–39.7) 12.6 (7.7–34.2) 48.7 (21.9–159.4) 20.6 (11.8–48.2) 54.4 (28.6–144.0) 13.5 (8.6–41.0) 18.3 (7.9–45.1)
  0.013* < 0.001*** 0.005** 0.893
  1. Data are presented by median and interquartile range (Q1–Q3)
  2. TAT thrombin–antithrombin complex, INR international normalized ratio, aPTT activated partial thromboplastin time, CRP C-reactive protein, PCT procalcitonin, PT index prothrombin index, PG F1α prostaglandin F1α, 11d-TX B2  11-dehydro Thromboxane B2
  3. A P value < 0.05 was considered statistically significant. Concerning symbolism and higher orders of significance: *P < 0.05, **P < 0.01, ***P < 0.001