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Annals of Intensive Care

Table 2 Laboratory parameters, ELISA and LC–MS measurements

From: Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Parameter

Baseline

Pre

Onset

24 h

48 h

7d

Healthy

Surgical

Surgical

Sepsis

Surgical

Sepsis

Surgical

Sepsis

Surgical

Sepsis

Leucocytes (1/nL)

6.16 (5.11–7.58)

6.14 (4.53–8.42)

12.18 (9.71–14.89)

19.21 (7.74–27.31)

11.71 (8.96–13.95)

19.86 (12.51–33.36)

9.51 (7.64–12.00)

19.95 (12.31–30.84)

10.35 (7.65–13.30)

14.21 (9.52–20.05)

 

0.039*

< 0.001***

< 0.001***

0.115

CRP (mg/L)

2.00 (2.00–2.85)

2.00 (2.00–6.65)

2.70 (2.00–9.85)

218.90 (144.05–269.08)

133.70 (90.63–157.40)

263.25 (159.75–320.30)

143.30 (112.10–162.30)

179.00 (116.25–293.05)

68.30 (29.45–130.70)

120.90 (72.30–158.10)

 

< 0.001***

< 0.001***

0.041*

0.150

PCT (ng/mL)

0.05 (0.05–0.05)

0.05 (0.05–0.07)

0.09 (0.05–0.19)

17.54 (1.68–48.18)

1.08 (0.43–2.18)

11.96 (3.27–35.07)

0.78 (0.36–1.49)

8.99 (1.77–28.69)

0.11 (0.10–0.81)

1.03 (0.47–1.45)

 

< 0.001***

< 0.001***

< 0.001***

0.008**

TAT (ng/mL)

3.30 (2.40–6.60)

9.90 (6.33–11.35)

9.90 (6.68–11.70)

12.85 (11.16–14.83)

9.23 (5.91–13.38)

12.53 (10.84–15.28)

10.30 (5.35–12.95)

13.73 (11.28–17.48)

10.90 (6.83–13.40)

14.70 (11.63–18.45)

 

< 0.001***

0.003**

0.001**

0.021*

D-dimer (mg/L)

0.37 (0.26–0.57)

0.48 (0.34–0.85)

3.55 (1.85–4.13)

7.59 (4.54–13.85)

3.50 (2.23–4.10)

6.94 (4.16–12.27)

2.41 (1.85–3.38)

6.77 (4.14–11.87)

4.68 (3.78–5.84)

5.47 (4.32–7.43)

 

< 0.001***

0.001**

< 0.001***

0.412

PT index (%)

109.5 (104.70–117.30)

94.00 (88.30–100)

91.00 (78.20–98.75)

68.75 (46.85–76.35)

70.05 (61.30–84.40)

65.80 (53.63–85.65)

94.00 (85.70–100.90)

81.00 (65.75–92.13)

96.80 (89.85–113.80)

81.90 (71.40–91.60)

 

< 0.001***

0.304

0.008**

0.004**

aPTT (s)

24.00 (22.65–25.90)

23.80 (22.65–25.90)

22.00 (20.60–23.95)

32.90 (28.45–37.80)

26.35 (24.53–28.48)

37.80 (31.33–44.53)

26.30 (23.80–28.00)

33.90 (27.65–40.55)

24.50 (21.50–27.05)

27.90 (26.10–35.00)

 

< 0.001***

< 0.001***

< 0.001***

0.009**

Platelet count (1/nL)

249.00 (209.50–275.75)

183.00 (167.50–232.50)

200.00 (172.00–248.50)

181.50 (101.50–229.50)

156.00 (133.00–191.80)

152.5 (59.30–253.00)

156.00 (137.00–197.00)

142.00 (68.00–255.00)

264.00 (246.00–315.50)

258.00 (204.50–377.50)

 

0.157

0.408

0.252

0.755

PG F1α (pg/mL)

22.9 (20.7–48.0)

82.0 (45.8–121.4)

54.9 (28.3–71.2)

278.3 (50.3–591.3)

10.1 (5.2–45.5)

431.0 (117.9–972.2)

7.7 (2.0–27.9)

283.9 (97.7–1165.8)

7.5 (1.2–59.1)

345.2 (48.4–689.0)

 

< 0.001***

< 0.001***

< 0.001***

0.016*

11d-TX B2 (pg/mL)

45.6 (36.9–73.4)

8.3 (5.1–19.8)

9.5 (5.6–14.6)

18.7 (9.6–39.7)

12.6 (7.7–34.2)

48.7 (21.9–159.4)

20.6 (11.8–48.2)

54.4 (28.6–144.0)

13.5 (8.6–41.0)

18.3 (7.9–45.1)

 

0.013*

< 0.001***

0.005**

0.893

  1. Data are presented by median and interquartile range (Q1–Q3)
  2. TAT thrombin–antithrombin complex, INR international normalized ratio, aPTT activated partial thromboplastin time, CRP C-reactive protein, PCT procalcitonin, PT index prothrombin index, PG F1α prostaglandin F1α, 11d-TX B2  11-dehydro Thromboxane B2
  3. A P value < 0.05 was considered statistically significant. Concerning symbolism and higher orders of significance: *P < 0.05, **P < 0.01, ***P < 0.001
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