Table 1 Patient characteristics at inclusion according to the presence or absence of severe acute kidney injury (AKI AKIN 2 or 3 at day 3)

Age (years)

66 [54.5; 76.5]

73 [59; 75]

57.5 [47; 77.8]

0.529

Sex. M/F

40/25

24/11

16/14

0.307

Preexisting conditions

Chronic arterial hypertension

33 (50.8%)

24 (68.6%)

9 (30%)

0.003

Diabetes

15 (23.1%)

12 (34.3%)

3 (10%)

0.021

Liver cirrhosis

5 (7.7%)

4 (11.4%)

1 (3.3%)

0.363

Treatment at admission

ACE inhibitor

20 (30.8%)

14 (40%)

6 (20%)

0.108

NSAIDs

6 (9.2%)

5 (14.3%)

1 (3.3%)

0.205

Mechanical ventilation

52 (80%)

31 (88.6%)

21 (70%)

0.118

SAPS II

53 [41.5; 66.5]

56 [48; 70]

50.5 [39.3; 64.3]

0.108

SOFA score total (24 h)

10 [8, 13]

12 [10, 14]

9 [6, 12]

0.004

Respiratory

3 [2, 4]

3 [2, 4]

3 [1.8; 3]

0.02

Cardiovascular

4 [4, 4]

4 [4, 4]

4 [4, 4]

0.128

Neurologic

0 [0; 0]

0 [0; 0]

0 [0; 0.3]

0.900

Hepatic

0 [0; 1.5]

1 [0; 2]

0 [0; 1.25]

0.521

Hematologic

1 [0; 2]

1 [0; 2]

1 [0; 2]

0.756

Renal

1 [0; 4]

3 [0; 4]

0.5 [0; 1]

0.002

Serum creatinine (μmol/L)

119.5 [75.5; 158.2]

127.5 [99.5; 210.3]

105 [62; 127.3]

0.009

Arterial lactate (mmol/L)

2 [1.3; 3.3]

2 [1.4; 4.9]

1.8 [1.1; 2.7]

0.035

Community-acquired infection

43 (66%)

24 (69%)

19 (63%)

0.794

Source of infection

Lung

22 (33.8%)

10 (28.6%)

12 (40%)

–

Urinary tract

11 (16.9%)

7 (20%)

4 (13.3%)

–

Abdomen

11 (16.9%)

9 (25.7%)

2 (6.7%)

–

Central nervous system

1 (1.5%)

0 (0%)

1 (3.3%)

–

Gynecologic tract

1 (1.5%)

0 (0%)

1 (3.3%)

–

Bone

1 (1.5%)

1 (2.9%)

0 (0%)

–

ENT

2 (3.1%)

0 (0%)

2 (6.7%)

–

Vascular catheter

2 (3.1%)

0 (0%)

2 (6.7%)

–

Skin

5 (7.7%)

1 (2.9%)

4 (13.3%)

–

Unknown

10 (15.4%)

6 (17.1%)

4 (13.3%)

–

Type of organism

Gram-positive

16 (24.6%)

9 (25.7%)

7 (23.3%)

*

Gram-negative


27 (41.5%)

16 (45.7%)

11 (36.7%)

*

Other

3 (4.6%)

1 (2.9%)

2 (6.7%)

*

Not identified

21 (32.3%)

9 (25.7%)

12 (40%)

*