Fixed effects

Estimate

95% confidence interval

p value


Global cardiac function

Ees (mmHg ml^{−1})

44.89

34.28 to 55.49

< 0.001

Ea (mmHg ml^{−1})

− 29.47

− 33.26 to − 25.68

< 0.001

LV EDV (ml)

− 0.12

− 0.15 to − 0.08

< 0.001

Heart rate (bpm)

0.17

0.05 to 0.29

0.006

Diastolic function

LV β constant (a.u.)

1340.3

474.9 to 1932.6

< 0.001

τ (ms)

− 1.28

− 1.49 to − 1.07

< 0.001

VAC (Ea/Ees) (a.u.)

− 10.6

− 11.85 to − 9.37

< 0.001

LV mechanical efficiency (%)

0.87

0.85 to 0.90

< 0.001

 Estimate reflects the average change in the LVEF per unit increase of each fixed effect
 Ees left ventricular endsystolic elastance; Ea effective arterial elastance, LV left ventricle, EDV enddiastolic volume, EDPVR slope of the enddiastolic pressure–volume relationship, β LV chamber stiffness constant obtained from the enddiastolic pressurevolume relationship, τ (tau) time constant of the isovolumetric LV pressure relaxation, VAC ventriculoarterial coupling