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Table 2 Ventilator settings averaged on day 1–3, arterial blood gas, and fluid overload in patients with and without acute kidney injury

From: Factors associated with acute kidney injury in acute respiratory distress syndrome

Ventilator settings No AKI (113) AKI (244) p Missing (%)
VT, median (IQR), mL 451 (401–502) 487 (422–551) 0.01a 35 (9.8)
VT, median (IQR), (mL/kg PBW) 7.4 (6.7–8.6) 7.5 (6.8–8.5) 0.89 35 (9.8)
PEEP, median (IQR), cm H2O 10.7 (8–13.3) 10 (8–14) 0.57 32 (9.0)
FiO2, median (IQR) 0.67 (0.54–0.8) 0.7 (0.57–0.87) 0.23 29 (8.1)
Pplat, median (IQR), cm H2O 27 (23–31) 27.2 (22.9–33.1) 0.38 158 (44.3)
Pplat > 30 cm H2O (%) 18 (30.5) 51 (36.4) 0.42 158 (44.3)
DP, median (IQR), cm H2O 15 (11.3–18.5) 14.8 (12–19) 0.82 158 (44.3)
Mean airway pressure, median (IQR), cm H2O 17.3 (14.3–20.7) 18 (14.7–21.5) 0.16 66 (18.5)
Ppeak, mean (SD), cm H2O 29.6 (6.5) 31.2 (7.3) 0.08 62 (17.4)
Minute ventilation, median (IQR), L/min 10.7 (8.5–11.9) 11.4 (9.7–13.1) 0.01a 63 (17.6)
Lung protective ventilation, n (%)b 26 (35.1) 64 (36.2) 0.88 106 (29.7)
 Arterial blood gases     
Arterial pH, median (IQR) 7.39 (7.34–7.43) 7.35 (7.3–7.41) < 0.001a 28 (7.8)
Arterial pH on day 1 7.38 (7.32–7.42) 7.34 (7.27–7.4) 0.005a 47 (13.2)
Serum HCO3, median (IQR), mEq/L 25 (22.5–28) 22 (18.3–25.3) < 0.001a 25 (7.0)
Serum HCO3 on day 1 25 (22–29) 21 (18–26) < 0.001a 46 (12.9)
Serum lactate, median (IQR), mmol/L 1.8 (1.3–2.3) 2.2 (1.5–3.8) < 0.001a 53 (14.8)
Serum lactate on day 1 1.8 (1.4–2.6) 2.6 (1.5–5.0) < 0.001a 90 (25.2)
PaCO2, median (IQR), mm Hg 45 (39–50.4) 42 (36–48.9) 0.02a 28 (7.8)
PaO2, median (IQR), mm Hg 87 (76–104) 88 (76–111) 0.68 28 (7.8)
PaO2:FiO2, median (IQR) 139 (107–180) 138 (99–187) 0.72 31 (8.7)
Oxygenation index, median (IQR) 13.8 (7.9–19.5) 14.3 (9.1–23.8) 0.11 68 (19.0)
Fluid overload, median (IQR), %     
 Day 1 0.2 (− 0.5 to 2.8) 1 (− 0.3 to 3.1) 0.17 117 (32.8)
 Day 2 1.5 (− 0.2 to 3.9) 3.4 (0.8–7.1) < 0.001 111 (31.1)
 Day 3 1.8 (− 0.5 to 5.2) 4.9 (1.8–9.2) < 0.001 115 (32.2)
  1. AKI acute kidney injury, DP driving pressure, FiO2 fraction of inspired oxygen, HCO3 bicarbonate, IQR interquartile range, PaCO2 partial pressure of carbon dioxide in arterial blood, PaO2 partial pressure of oxygen in arterial blood, PBW predicted body weight, PEEP positive end-expiratory pressure, Ppeak peak inspiratory pressure, Pplat plateau pressure, SD standard deviation, VT tidal volume
  2. ap < 0.05
  3. bTidal volume ≤ 8 mL/kg PBW and inspiratory plateau pressure ≤ 30 cm H2O
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