Factors associated with acute kidney injury in acute respiratory distress syndrome

Panitchote, Anupol; Mehkri, Omar; Hastings, Andrei; Hanane, Tarik; Demirjian, Sevag; Torbic, Heather; Mireles-Cabodevila, Eduardo; Krishnan, Sudhir; Duggal, Abhijit

doi:10.1186/s13613-019-0552-5

Annals of Intensive Care

Table 2 Ventilator settings averaged on day 1–3, arterial blood gas, and fluid overload in patients with and without acute kidney injury

From: Factors associated with acute kidney injury in acute respiratory distress syndrome

Ventilator settings	No AKI (113)	AKI (244)	p	Missing (%)
VT, median (IQR), mL	451 (401–502)	487 (422–551)	0.01^a	35 (9.8)
VT, median (IQR), (mL/kg PBW)	7.4 (6.7–8.6)	7.5 (6.8–8.5)	0.89	35 (9.8)
PEEP, median (IQR), cm H₂O	10.7 (8–13.3)	10 (8–14)	0.57	32 (9.0)
FiO₂, median (IQR)	0.67 (0.54–0.8)	0.7 (0.57–0.87)	0.23	29 (8.1)
Pplat, median (IQR), cm H₂O	27 (23–31)	27.2 (22.9–33.1)	0.38	158 (44.3)
Pplat > 30 cm H₂O (%)	18 (30.5)	51 (36.4)	0.42	158 (44.3)
DP, median (IQR), cm H₂O	15 (11.3–18.5)	14.8 (12–19)	0.82	158 (44.3)
Mean airway pressure, median (IQR), cm H₂O	17.3 (14.3–20.7)	18 (14.7–21.5)	0.16	66 (18.5)
Ppeak, mean (SD), cm H₂O	29.6 (6.5)	31.2 (7.3)	0.08	62 (17.4)
Minute ventilation, median (IQR), L/min	10.7 (8.5–11.9)	11.4 (9.7–13.1)	0.01^a	63 (17.6)
Lung protective ventilation, n (%)^b	26 (35.1)	64 (36.2)	0.88	106 (29.7)
Arterial blood gases
Arterial pH, median (IQR)	7.39 (7.34–7.43)	7.35 (7.3–7.41)	< 0.001^a	28 (7.8)
Arterial pH on day 1	7.38 (7.32–7.42)	7.34 (7.27–7.4)	0.005^a	47 (13.2)
Serum HCO₃, median (IQR), mEq/L	25 (22.5–28)	22 (18.3–25.3)	< 0.001^a	25 (7.0)
Serum HCO₃ on day 1	25 (22–29)	21 (18–26)	< 0.001^a	46 (12.9)
Serum lactate, median (IQR), mmol/L	1.8 (1.3–2.3)	2.2 (1.5–3.8)	< 0.001^a	53 (14.8)
Serum lactate on day 1	1.8 (1.4–2.6)	2.6 (1.5–5.0)	< 0.001^a	90 (25.2)
PaCO₂, median (IQR), mm Hg	45 (39–50.4)	42 (36–48.9)	0.02^a	28 (7.8)
PaO₂, median (IQR), mm Hg	87 (76–104)	88 (76–111)	0.68	28 (7.8)
PaO₂:FiO₂, median (IQR)	139 (107–180)	138 (99–187)	0.72	31 (8.7)
Oxygenation index, median (IQR)	13.8 (7.9–19.5)	14.3 (9.1–23.8)	0.11	68 (19.0)
Fluid overload, median (IQR), %
Day 1	0.2 (− 0.5 to 2.8)	1 (− 0.3 to 3.1)	0.17	117 (32.8)
Day 2	1.5 (− 0.2 to 3.9)	3.4 (0.8–7.1)	< 0.001	111 (31.1)
Day 3	1.8 (− 0.5 to 5.2)	4.9 (1.8–9.2)	< 0.001	115 (32.2)

AKI acute kidney injury, DP driving pressure, FiO₂ fraction of inspired oxygen, HCO₃ bicarbonate, IQR interquartile range, PaCO₂ partial pressure of carbon dioxide in arterial blood, PaO₂ partial pressure of oxygen in arterial blood, PBW predicted body weight, PEEP positive end-expiratory pressure, Ppeak peak inspiratory pressure, Pplat plateau pressure, SD standard deviation, VT tidal volume
^ap < 0.05
^bTidal volume ≤ 8 mL/kg PBW and inspiratory plateau pressure ≤ 30 cm H₂O

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