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Table 3 Respiratory profile parameters for the eight different conditions tested

From: Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study

Parameter (median [IQR])

Spontaneous breathing (SB)

Assisted breathing without resistance

Assisted breathing with resistance

Without resistance

With resistance

p values

PS low

PS high

NAVA

p values

PS low

PS high

NAVA

p values

MV (L/min)

9.9 (8.7–14.4)

8.9 (7.1–10.5)

p = 0.03

13.7 (10.6–18.5)

16.4 (10.7–24.4)

12.9 (11.1–18.5)

*p = 0.001,

p < 0.05 for all the ventilation modalities compared to SB without resistance

p > 0.05 for all pairwise comparisons between PS low, PS high and NAVA

11.1 (10.5–12.1)

13.7 (10.9–18.0)

11.1 (9.9–12.5)

#p = 0.001

p < 0.05 for all the ventilation modalities compared to SB with resistance

p < 0.05 between PS high and PS low and between PS high and NAVA

RR (br/min)

14.6 (12.5–15.7)

10.9 (8.7–12.0)

p < 0.001

15.5 (12.9–17.7)

15.3 (13.7–16.5)

14.0 (12.1–17.8)

*p = 0.22

12.7 (10.2–13.6)

12.5 (10.6–13.8)

12.1 (10.4–16.5)

#p = 0.053

VT (L)

0.81 (0.65–1.00)

0.90 (0.70–1.05)

p = 0.54

0.99 (0.79–1.20)

0.99 (0.69–1.71)

0.92 (0.74–1.21)

*p = 0.004

p < 0.05 for all the ventilation modalities compared to SB without resistance.

p > 0.05 for all pairwise comparisons between PS low, PS high and NAVA

0.88 (0.86–1.01)

1.33 (0.96–1.48)

0.90 (0.78–1.04)

#p = 0.055

Tin (ms)

1.76 (1.48–2.00)

2.41 (1.91–2.67)

p < 0.001

1.54 (1.38–1.78)

1.45 (1.36–1.73)

1.68 (1.29–1.91)

*p = 0.46

1.78 (1.63–2.01)

1.78 (1.62–1.96)

1.91 (1.43–2.15)

#p = 0.027.

p < 0.05 between SB with resistance and PS low, SB with resistance and PS high and SB with resistance and NAVA

Tiex (ms)

0.17 (0.10–0.22)

0.27 (0.22–0.38)

p < 0.001

0.20 (0.14–0.25)

0.24 (0.11–0.29)

0.24 (0.21–0.31)

*p = 0.23

0.31 (0.21–0.33)

0.41 (0.31–0.64)

0.28 (0.20–0.40)

#p = 0.039.

p < 0.05 between SB with resistance and PS high, and between PS low and PS high

Ti/Ttot

0.41 (0.40–0.45)

0.44 (0.42–0.47)

p = 0.10

0.41 (0.39–0.44)

0.42 (0.37–0.45)

0.44 (0.41–0.47)

*p = 0.17

0.43 (0.40–0.44)

0.41 (0.39–0.45)

0.44 (0.39–0.45)

#p = 0.97

  1. For the multiple comparisons (Friedman analyses), only the subjects for whom all the conditions compared could be recorded were considered. The corresponding median values summarize these patients only
  2. MV minute ventilation, RR respiratory rate, VT tidal volume, Tin neural inspiratory time, Tiex inspiratory time in excess, PS Pressure support, NAVA neurally adjusted ventilatory assist
  3. * Comparison between spontaneous non-assisted breathing without resistance and assisted breathing without resistance under PS low, PS high and NAVA
  4. #Comparison between spontaneous non-assisted breathing with resistance and assisted breathing with resistance under PS low, PS high and NAVA