Parameter (median [IQR]) | Spontaneous breathing (SB) | Assisted breathing without resistance | Assisted breathing with resistance | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Without resistance | With resistance | p values | PS low | PS high | NAVA | p values | PS low | PS high | NAVA | p values | |
MV (L/min) | 9.9 (8.7–14.4) | 8.9 (7.1–10.5) | p = 0.03 | 13.7 (10.6–18.5) | 16.4 (10.7–24.4) | 12.9 (11.1–18.5) | *p = 0.001, p < 0.05 for all the ventilation modalities compared to SB without resistance p > 0.05 for all pairwise comparisons between PS low, PS high and NAVA | 11.1 (10.5–12.1) | 13.7 (10.9–18.0) | 11.1 (9.9–12.5) | #p = 0.001 p < 0.05 for all the ventilation modalities compared to SB with resistance p < 0.05 between PS high and PS low and between PS high and NAVA |
RR (br/min) | 14.6 (12.5–15.7) | 10.9 (8.7–12.0) | p < 0.001 | 15.5 (12.9–17.7) | 15.3 (13.7–16.5) | 14.0 (12.1–17.8) | *p = 0.22 | 12.7 (10.2–13.6) | 12.5 (10.6–13.8) | 12.1 (10.4–16.5) | #p = 0.053 |
VT (L) | 0.81 (0.65–1.00) | 0.90 (0.70–1.05) | p = 0.54 | 0.99 (0.79–1.20) | 0.99 (0.69–1.71) | 0.92 (0.74–1.21) | *p = 0.004 p < 0.05 for all the ventilation modalities compared to SB without resistance. p > 0.05 for all pairwise comparisons between PS low, PS high and NAVA | 0.88 (0.86–1.01) | 1.33 (0.96–1.48) | 0.90 (0.78–1.04) | #p = 0.055 |
Tin (ms) | 1.76 (1.48–2.00) | 2.41 (1.91–2.67) | p < 0.001 | 1.54 (1.38–1.78) | 1.45 (1.36–1.73) | 1.68 (1.29–1.91) | *p = 0.46 | 1.78 (1.63–2.01) | 1.78 (1.62–1.96) | 1.91 (1.43–2.15) | #p = 0.027. p < 0.05 between SB with resistance and PS low, SB with resistance and PS high and SB with resistance and NAVA |
Tiex (ms) | 0.17 (0.10–0.22) | 0.27 (0.22–0.38) | p < 0.001 | 0.20 (0.14–0.25) | 0.24 (0.11–0.29) | 0.24 (0.21–0.31) | *p = 0.23 | 0.31 (0.21–0.33) | 0.41 (0.31–0.64) | 0.28 (0.20–0.40) | #p = 0.039. p < 0.05 between SB with resistance and PS high, and between PS low and PS high |
Ti/Ttot | 0.41 (0.40–0.45) | 0.44 (0.42–0.47) | p = 0.10 | 0.41 (0.39–0.44) | 0.42 (0.37–0.45) | 0.44 (0.41–0.47) | *p = 0.17 | 0.43 (0.40–0.44) | 0.41 (0.39–0.45) | 0.44 (0.39–0.45) | #p = 0.97 |