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Table 1 Clinical and biological characteristics on admission, according to the type of diabetes

From: Initial management of diabetic ketoacidosis and prognosis according to diabetes type: a French multicentre observational retrospective study

Characteristics at admission

N

Total (n = 122)

Type 1 diabetes (n = 60)

Type 2 or secondary diabetes (n = 28)

Newly diagnosed diabetes (n = 34)

p value

Age (years)

122

43 [24–59]

27 [20–45]

61 [52–70]

42 [27–54]

< 0.001

Women

122

61 (50.0)

31 (51.7)

13 (46.4)

17 (50.0)

0.901

BMI

82

23.3 [19.5–27.1]

21.3 [19.0–25.5]

23.9 [22.0–30.1]

24.2 [17.5–31.9]

0.136

Weight (kg)

95

65 [55–77]

60 [53–71]

70 [61–80]

69 [55–88]

0.048

HbA1C (%)

65

11.1 [8.9–12.8]

10.6 [8.0–12.4]

10.4 [8.9–12.2]

12.7 [11.1–14.0]

0.019

Medical background

 Diabetic microangiopathy

114

15 (13.2)

7 (13.2)

8 (28.6)

0 (0)

0.002

 Diabetic macroangiopathy

114

9 (7.9)

3 (5.6)

6 (22.2)

0 (0)

0.007

 Chronic renal failure

117

4 (3.4)

0 (0)

4 (14.3)

0 (0)

0.003

 Cancer

117

7 (6.0)

2 (3.6)

4 (14.3)

1 (3.0)

0.137

Triggering factor

 Poor adherence to treatment

121

49 (40.5)

40 (66.7)

9 (33.3)

0 (0)

< 0.001

 Infection

121

29 (24)

12 (20)

7 (25.9)

10 (24.0)

0.569

 Post-surgery

121

1 (0.8)

1 (1.7)

0 (0)

0 (0)

1.000

 Other

121

34 (28.1)

20 (33.3)

8 (29.6)

6 (17.6)

0.261

Variables

 HR (/min)

119

110 [95–126]

110 [97–126]

100 [88–120.5]

110 [99–128]

0.141

 SBP (mmHg)

119

127 [110–140]

124 [107–135]

133 [110–150]

130 [119–153]

0.065

 DBP (mmHg)

119

71 [60–85]

69 [59–81]

74 [57–84]

78 [69–89]

0.014

 RR (/min)

91

23 [19–29]

24 [20–30]

26 [19–30]

22 [18–25]

0.150

Arterial blood gas

 pH

120

7.16 [7.03–7.24]

7.13 [6.99–7.24]

7.19 [7.11–7.26]

7.13 [7.05–7.24]

0.192

 Bicarbonate (mmol/l)

119

6.5 [4.0–10.3]

6.0 [3.1–8.9]

7.8 [4.1–11.7]

6.6 [4.0–10.1]

0.153

 PaCO2 (mmHg)

117

19 [13–24]

18 [13–22]

20 [15–26]

16 [12–25]

0.092

 PaO2 (mmHg)

116

120 [98–137]

124 [102–139]

109 [88–126]

122 [104–136]

0.232

 Oxygen therapy

117

19 (16.2)

11 (19.0)

10 (40.0)

8 (24.2)

0.126

 Intubated patient

115

7 (6.1)

4 (6.9)

2 (8.0)

1 (3.1)

0.775

Blood glucose (mmol/l)

109

32 [24–43.4]

30 [22.3–40]

40.5 [28–50.9]

28.8 [21.6–39.8]

0.261

Ketonuria (cross)

80

    

0.557

 1, n (%)

 

2 (2.5)

0 (0)

1 (5.3)a

1 (4.8)a

 

 2, n (%)

 

10 (12.5)

4 (10)

3 (15.8)

3 (14.3)

 

 3, n (%)

 

19 (23.75)

9 (22.5)

6 (31.6)

4 (19.1)

 

 4, n (%)

 

49 (61.25)

27 (67.5)

9 (47.4)

13 (61.9)

 

Venous blood test

 Na+ (mmol/l)

119

133 [128–138]

133 [131–138]

129 [125–137]

134 [128–140]

0.072

 K+ (mmol/l)

120

4.9 [4.25–5.75]

4.9 [4.3–5.8]

5.1 [4.1–6.1]

4.7 [4.2–5.6]

0.677

 Cl (mmol/l)

117

96 [89–102]

96 [90–103]

91 [83–101]

97 [91–103]

0.018

 Protein (g/l)

116

79 [68.5–85]

78 [69–85]

68 [62–80]

84 [76–87]

< 0.001

 Urea (mmol/l)

120

8.8 [6.5–17.4]

8.2 [5.7–13.1]

17.3 [9.7–21]

7.4 [5.5–16]

0.001

 Creatinine (mg/dl)

119

1.44 [0.92–1.99]

1.22 [0.83–1.82]

1.84 [1.36–2.99]

1.22 [0.97–1.98]

0.012

 Haemoglobin (g/dl)

119

14.7 [12.7–16.0]

14.2 [12.5–16.4]

13.9 [11.4–15.2]

15.6 [14.7–16.5]

0.005

 Leukocytes (G/l)

98

16.6 [10.1–23.4]

17.2 [10.5–26.0]

16.3 [9.9–23.5]

15.3 [9.2–19.4]

0.169

 Lipasemia (UI/l)

59

51 [14–180]

38 [9–123]

34 [12–157]

115 [41–239]

0.856

  1. Data are presented as the median [IQR] or the n (%)
  2. BMI: body mass index; HbA1C: glycohemoglobin; HR: heart rate; SBP: systolic blood pressure; DBP: diastolic blood pressure; RR: respiratory rate; PaCO2: partial pressure of carbon dioxide in arterial blood; PaO2: partial pressure of oxygen in arterial blood
  3. aThe two patients with only one cross of ketonuria had a ketonemia above 3 mmol/l