Table 1 Demographic, clinical and hemodynamic characteristics of study subjects
All patients (n = 28) | Sepsis (n = 13) | Septic shock (n = 15) | Controls (n = 15) | |
|---|---|---|---|---|
Demographic and clinical characteristics | ||||
Age (in years) | 70 (62–78.5) | 70 (65–78) | 69 (56–79) | 35 (25–36)† |
Male, n (%) | 17 (61%) | 8 (63%) | 7 (47%) | 8 (53%) |
APACHE II score | 23 (18–29) | 17 (15–22)* | 27 (21–29) | NA |
SOFA score | 10 (7–12) | 7 (6–11)* | 11 (10–12) | NA |
Arterial lactate, mmol/l | 4.0 (2.4–5.3) | 5.0 (2.4–7.0) | 4.0 (2.3–7.0) | NA |
Mechanical ventilation, n (%) | 7 (25%) | 3 (23%) | 4 (27%) | NA |
Renal replacement therapy, n (%) | 5 (18%) | 2 (15%) | 3 (20%) | NA |
ICU survivors, n, (%) | 23 (82%) | 11 (85%) | 12 (80%) | NA |
28-day survivors n, (%) | 20 (71%) | 9 (70%) | 11 (65%) | NA |
Source of sepsis n, (%) | NA | |||
Abdominal | 12 (43%) | 6 (46%) | 6 (40%) | |
Respiratory | 8 (29%) | 3 (23%) | 5 (33%) | |
Urinary | 4 (14%) | 3 (23%) | 1 (7%) | |
Other | 4 (14%) | 1 (8%) | 3 (20%) | |
Hemodynamic characteristics | ||||
Baseline systolic blood pressure (mm Hg) | 99 (92–107) | 100 (98–106) | 97 (92–108) | 115 (112–127)† |
Baseline mean arterial pressure (mm Hg) | 67 (65–74) | 74 (69–79)** | 65 (64–67) | 91 (87.5–98.5)† |
Volume of fluids before inclusion (ml) | 2887 (2402–3205) | 2402 (2315–2608) | 3270 (2428–3420) | NA |
Baseline dose of noradrenaline (mcg/kg/min) | 0.04 (0–1) | 0** | 0.1 (0.06–0.25) | NA |
Heart rate (beats/min) | 113 (92–137) | 113 (92–114) | 128 (110–145) | 63 (59–70.5)† |
Mottling score | NA | |||
0 | 22 (79%) | 12 (92%) | 10 (67%) | |
1 | 2 (7%) | 0 | 2 (13%) | |
2 | 3 (11%) | 1 (8%) | 2 (13%) | |
3 | 1 (3%) | 0 | 1 (7%) | |