Table 3 Characteristics of patients according to the severity of hypernatremia at the time of desmopressin administration
Na ≤ 153 mmol/L n = 20 | Na > 153 mmol/L n = 19 | p | |
|---|---|---|---|
Age, years | 35 ± 9 | 34 ± 17 | 0.823 |
Weight, kg | 77.0 ± 11 | 75 ± 10 | 0.599 |
Male, n (%) | 18 (90) | 16 (84) | 0.661 |
ISS | 30 [25–41] | 32 [25–46] | 0.722 |
Natremia 12 h before desmopressin | 143 [139–145] | 152 [150–155] | < 0.001 |
Natremia increase over the last 12 h before desmopressin | 4 [2–6] | 6 [5–9] | 0.07 |
Natremia at the time of desmopressin | 148 [145–149] | 158 [155–161] | – |
Mean ICP (1st day desmo), mmHg | 18 ± 13 | 18 ± 8 | 0.206 |
Max ICP (1st day desmo), mmHg | 23 ± 17 | 24 ± 11 | 0.325 |
Any Osmotherapy 1st day desmo, n (%) | 4 (20) | 14 (74) | 0.001 |
Mannitol, n (%) | 2 | 11 | – |
Hypertonic saline, n (%) | 2 | 5 | – |
Fixed pupils at admission, n (%) | 10 (50) | 11 (58) | 0.751 |
Diuresis, mL | 4638 [3520–5385] | 4397 [3595–5240] | 0.491 |
APACHE II | 20 [14–40] | 23 [20–33] | 0.599 |
IMPACT predicted 6-month mortality | 25 [17–43] | 30 [19–44] | 0.623 |
Mortality, n (%) | 7 (35) | 9 (47) | 0.433 |