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Annals of Intensive Care

Table 1 Patient characteristics

From: Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

 

Data available

All patients, n = 619

90d survivors, n = 439 (70.9%)

Non-survivors, n = 180 (29.1%)

p value

Age (years)

619

66 [55 to 75]

62 [52 to 73]

73 [62 to 80]

< 0.001

Sex; female

619

223 (36.0%)

154 (35.1%)

69 (38.3%)

0.462

Body mass index (kg/m2)

618

26.8 [23.6 to 30.1]

27.4 [24.1 to 30.9]

25.4 [23.0 to 27.9]

< 0.001

Comorbidities

 Hypertension

616

329 (53.2%)

229 (52.4%)

100 (55.9%)

0.477

 Coronary artery disease or ASO

609

89 (14.4%)

55 (12.7%)

34 (19.3%)

0.043

 Chronic heart failure

613

71 (11.5%)

38 (8.7%)

33 (18.5%)

0.001

 COPD

612

79 (12.8%)

56 (12.9%)

23 (12.9%)

> 0.999

 Chronic kidney disease (GFR < 60 mL/min/1.73 m2)

615

42 (6.8%)

23 (5.3%)

19 (10.7%)

0.021

 Diabetes

619

158 (25.5%)

121 (27.6%)

37 (20.6%)

0.084

 Baseline creatinine (µmol/L)

436

76 [61 to 92]

76 [61 to 91]

76 [62 to 98]

0.458

 Pre-ICU chronic corticosteroid use

615

77 (12.4%)

41 (9.3%)

36 (20.0%)

< 0.001

 Pre-ICU immunosuppression

614

56 (9.0%)

36 (8.2%)

20 (11.1%)

0.279

 Pre-ICU radiocontrast

616

122 (19.7%)

93 (21.2%)

29 (16.1%)

0.150

 Pre-ICU aminoglycoside

618

7 (1.1%)

2 (0.5%)

5 (2.8%)

0.013

 Pre-ICU NSAID

582

94 (15.2%)

69 (15.7%)

25 (13.9%)

0.621

 Pre-ICU amphotericin B

616

3 (0.5%)

0 [0.0%)

3 (1.7%)

0.024

 Surgical admission

619

149 (24.1%)

115 (26.2%)

34 (18.9%)

0.062

Infection source

 CNS

619

18 (2.9%)

16 (3.6%)

2 (1.1%)

0.114

 Lung

619

296 (47.8%)

209 (47.6%)

87 (48.3%)

0.929

 GI tract

619

156 (25.2%)

108 (24.6%)

48 (26.7%)

0.611

 Urinary tract

619

46 (7.4%)

34 (7.7%)

12 (6.7%)

0.737

 Skin and soft tissue

619

55 (8.9%)

45 (10.3%)

10 (5.6%)

0.064

 Other

619

19 (3.1%)

10 (2.3%)

9 (5.0%)

0.12

 Time from hospital admission to ICU admission (h)

618

22 [9 to 59]

21 [8 to 53]

23 [11 to 74]

0.067

 First lactate (mmol/L)a

536

1.80 [1.10 to 3.31]

1.60 [1.00 to 2.87]

2.20 [1.30 to 5.75]

< 0.001

 First hematocrit (%)a

575

33 [29 to 37]

33 [29 to 37]

33 [28 to 37]

0.424

 Vasopressor within first 24 h

619

438 (70.8%)

300 (68.3%)

138 (76.7%)

0.041

 SOFA score at day 1

619

8 [6 to 10]

7 [6 to 9]

10 [7 to 13]

< 0.001

 SAPS II score

619

42 [33 to 54]

39 [31 to 47]

54 [41 to 68]

< 0.001

 SAPS II score without age and renal components

615

24 [18 to 32]

23 [17 to 29]

29 [22 to 29]

< 0.001

 AKI (any severity)b

619

316 (51.1%)

203 (46.2%)

113 (62.8%)

< 0.001

 AKI stage 1

619

122 (19.7%)

89 (20.3%)

33 (18.3%)

0.657

 AKI stage 2

619

54 (8.7%)

40 (9.1%)

14 (7.8%)

0.641

 AKI stage 3

619

140 (22.6%)

74 (16.9%)

66 (36.7%)

< 0.001

 RRT for AKI during ICU stay

619

101 (16.3%)

52 (11.8%)

49 (27.2%)

< 0.001

 Mechanical ventilation during ICU stay

619

404 (65.3%)

261 (59.5%)

143 (79.4%)

< 0.001

 Fluid input on day 0 normalized to hours (mL)c

619

247 [173 to 363]

238 [167 to 337]

285 [184 to 417]

0.003

 Cumulative balance %/weightd

579

1.06 [− 2.75 to 5.68]

0.15 [− 3.11 to 4.31]

4.13 [− 2.20 to 9.90]

< 0.001

 ICU length of stay (days)

618

4 [2 to 7]

4 [2 to 6]

5 [2 to 9]

0.022

  1. Categorical data reported as count (percentage) and continuous data as median [interquartile range, IQR]
  2. ASO arteriosclerosis obliterans, COPD chronic obstructive pulmonal disease, ICU intensive care unit, NSAID non-steroidal anti-inflammatory drug, CNS central nervous system, GI gastrointestinal, SOFA sequential organ failure assessment considering all six organ systems, SAPSII Simplified Acute Physiology Score II, AKI acute kidney injury, RRT renal replacement therapy
  3. aFirst value measured within first 6 h from ICU admission
  4. bAll AKI patients
  5. cFor details please see “Methods”
  6. dCumulative fluid accumulation at discharge/on day 5 during ICU stay as a percentage of body weight
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