Predictors of successful separation from high-flow nasal oxygen therapy in patients with acute respiratory failure: a retrospective monocenter study

Annals of Intensive Care

Table 3 Clinical and biological parameters under high-flow nasal oxygen therapy in the failure group, before separation and after failure

	Last values under HFOT before HFOT separation	First values under HFOT after HFOT resumption	p value
Temperature, °C	37.4 ± 0.8	37.4 ± 0.8	0.89
Respiratory rate, /min	22 ± 5	21 ± 5	0.52
Pulse oximetry, %	96 ± 2	96 ± 3	0.89
Systolic arterial pressure, mmHg	127 ± 19	131 ± 17	0.32
Heart rate, /min	94 ± 20	97 ± 20	0.28
Flow, L/min	43 ± 8	50 ± 5	0.001
FiO₂, %	48 ± 16	56 ± 15	0.12
SpO₂/FiO₂, %	217 ± 53	183 ± 41	0.03
ROX index	10.2 ± 3.0	9.1 ± 3.7	0.30
PaO₂, mmHg	96 ± 33	n = 16 84 ± 20	0.09
PaCO₂, mmHg	36 ± 8	n = 16 43 ± 20	0.18
pH, mmHg	7.44 ± 0.05	n = 16 7.42 ± 0.10	0.52
Serum bicarbonate, mmol/L	24 ± 5	n = 16 26 ± 5	0.08
PaO₂/FiO₂ under HFOT, mmHg	210 ± 72	n = 16 148 ± 38	0.006

HFOT high-flow nasal oxygen therapy, ICU intensive-care unit, FiO₂ fraction of inspired oxygen, PaO₂ partial pressure in oxygen, SpO₂ oxygen saturation, ROX SpO₂/FiO₂ to respiratory rate