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Table 3 Sedative anesthetics and depth of sedation

From: Use of MIRUS™ for MAC-driven application of isoflurane, sevoflurane, and desflurane in postoperative ICU patients: a randomized controlled trial

  Intravenous propofol sedation Inhalational VA sedation IV vs. VA
Gr. ISO [n = 10] Gr. SEVO [n = 10] Gr. DES [n = 10] All [n = 30] p value ISO [n = 10] SEVO [n = 10] DES [n = 10] All [n = 30] p value p value
Duration of sedation
 Propofol [h:min] 1:20 [1:00 to 3:14] 1:26 [1:00 to 1:45] 1:30 [1:00 to 4:27] 1:27 [1:00 to 2:16] 0.876   
 VA [h:min]   17:52 [16:37 to 20:38] 16:31 [10:26 to 37:26] 18:52 [14:9 to 33:48] 18:08 [14:46 to 21:34] 0.716  
Sedatives and analgesics
 Propofol [mg kg−1 h−1] 2.75 [2.14 to 3.09] 2.79 [1.78 to 3.36] 3.25 [2.91 to 4.20] 2.98 [2.32 to 3.33] 0.098   
 VA [MAC]   0.58 [0.56 to 0.59] 0.54 [0.50 to 0.60] 0. 56 [0.53 to 0.60] 0.58 [0.53 to 0.59] 0.326  
 etVA [vol. %]   0.57 [0.55 to 0.63] 0.84 [0.78 to 1.00] 3.21 [3.04 to 3.69] 0.84 [0.61 to 3.09] < 0.001 *1  
  *1: ISO vs. DES: p< 0.001, r = 0.84; SEVO vs. DES: p< 0.001, r = 0.84; ISO vs. SEVO: p< 0.001, r = 0.84
 Sufentanil [µg kg−1 h−1] 0.22 [0.12 to 0.26] 0.20 [0.16 to 0.29] 0.16 [0.14 to 0.33] 0.20 [0.14 to 0.28] 0.938 0.13 [0.08 to 0.21] 0.13 [0.05 to 0.20] 0.22 [0.15 to 0.34] 0.16 [0.10 to 0.23] 0.024 *2 0.104
  *2: ISO vs. DES: p= 0.035, r = 0.47; SEVO vs. DES: p= 0.011, r = 0.55; ISO vs. SEVO: p = 0.579
Depth of sedation
 Narcotrend Index [score] 32.4 [26.6 to 41.6] 32.1 [25.6 to 55.2] 40.5 [31.0 to 59.8] 33.1 [28.22 to 49.85] 0.403 33.0 [28.23 to 44.67] 37.3 [29.77 to 44.93] 37.9 [36.53 to 42.12] 37.1 [30.98 to 42.36] 0.665 0.775
 RASS [score] − 5.0 [− 5.0 to (− 4.8)] − 5.0 [− 5.0 to (− 5.0)] − 4.8 [− 5.0 to (− 3.0)] − 5.0 [− 5.0 to (− 4.4)] 0.165 − 3.0 [− 4.1 to (− 3.0)] − 3.3 [− 4.3 to (− 3.0)] − 3.0 [− 3.6 to (− 2.8)] − 3.0 [− 4.0 to (− 3.0)] 0.410 < 0.001
r = 0.52
  1. A MAC of 0.58 and a propofol infusion rate of 2.98 ml kg−1 h−1 led to a comparable depth of sedation as measured by Narcotrend Index. According to RASS, nurses judged VA sedated patients more ‘awake’ than propofol sedated patients. Values are given as median [1st–3rd quartiles]
  2. Gr. group