Table 3 Sedative anesthetics and depth of sedation

Duration of sedation

 Propofol [h:min]

1:20 [1:00 to 3:14]

1:26 [1:00 to 1:45]

1:30 [1:00 to 4:27]

1:27 [1:00 to 2:16]

0.876

–

–

–

–

 VA [h:min]

–

–

–

–

17:52 [16:37 to 20:38]

16:31 [10:26 to 37:26]

18:52 [14:9 to 33:48]

18:08 [14:46 to 21:34]

0.716

Sedatives and analgesics

 Propofol [mg kg⁻¹ h⁻¹]

2.75 [2.14 to 3.09]

2.79 [1.78 to 3.36]

3.25 [2.91 to 4.20]

2.98 [2.32 to 3.33]

0.098

–

–

–

–

 VA [MAC]

–

–

–

–

0.58 [0.56 to 0.59]

0.54 [0.50 to 0.60]

0. 56 [0.53 to 0.60]

0.58 [0.53 to 0.59]

0.326

 etVA [vol. %]

–

–

–

–

0.57 [0.55 to 0.63]

0.84 [0.78 to 1.00]

3.21 [3.04 to 3.69]

0.84 [0.61 to 3.09]

< 0.001 ^*1

^*1: ISO vs. DES: p < 0.001, r = 0.84; SEVO vs. DES: p < 0.001, r = 0.84; ISO vs. SEVO: p < 0.001, r = 0.84

 Sufentanil [µg kg⁻¹ h⁻¹]

0.22 [0.12 to 0.26]

0.20 [0.16 to 0.29]

0.16 [0.14 to 0.33]

0.20 [0.14 to 0.28]

0.938

0.13 [0.08 to 0.21]

0.13 [0.05 to 0.20]

0.22 [0.15 to 0.34]

0.16 [0.10 to 0.23]

0.024 ^*2

0.104

^*2: ISO vs. DES: p = 0.035, r = 0.47; SEVO vs. DES: p = 0.011, r = 0.55; ISO vs. SEVO: p = 0.579

Depth of sedation

 Narcotrend Index [score]

32.4 [26.6 to 41.6]

32.1 [25.6 to 55.2]

40.5 [31.0 to 59.8]

33.1 [28.22 to 49.85]

0.403

33.0 [28.23 to 44.67]

37.3 [29.77 to 44.93]

37.9 [36.53 to 42.12]

37.1 [30.98 to 42.36]

0.665

0.775

 RASS [score]

− 5.0 [− 5.0 to (− 4.8)]

− 5.0 [− 5.0 to (− 5.0)]

− 4.8 [− 5.0 to (− 3.0)]

− 5.0 [− 5.0 to (− 4.4)]

0.165

− 3.0 [− 4.1 to (− 3.0)]

− 3.3 [− 4.3 to (− 3.0)]

− 3.0 [− 3.6 to (− 2.8)]

− 3.0 [− 4.0 to (− 3.0)]

0.410

< 0.001

r = 0.52