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Table 1 Characteristics of all included studies

From: Prediction of mortality in adult patients with sepsis using six biomarkers: a systematic review and meta-analysis

AuthorYearCountryStudy designNAssayOutcome
Angiopoietin 1 and 2
 Parikh [35]2006USAProspective22ELISA (R&D Systems)Hospital mortality
 Kranidioti [31]2009GreeceProspective90ELISA (R&D Systems)28-day mortality
 Siner [37]2009USAProspective66ELISA (R&D Systems)28-day, ICU, and hospital mortality
 van der Heijden [38]2009NetherlandsProspective50ELISA (R&D Systems)28-day, ICU, and hospital mortality
 Davis [29]2010AustraliaProspective124ELISA (R&D Systems)28-day mortality
 Ricciuto [36]2011CanadaRetrospective70ELISA (R&D Systems)28-day mortality
 Fang [30]2015ChinaProspective495ELISA (Abcam)28-day mortality
 Lin [32]2015TaiwanProspective96ELISA (Sekisui Diagnostics)Hospital mortality
 Mikacenic [33]2015USARetrospective943Multiplex immunoassay (Meso Scale Discovery)28-day mortality
 Palud [34]2015FranceProspective20ELISA (RayBiotech)7-day, 10-day, and 28-day mortality
Total number of patients = 1976  
HMGB1
 Sunden-Cullberg [39]2005SwedenProspective64Western immunoblotting (Cocalico Biologicals)28-day mortality
 Gibot [40]2007FranceProspective42ELISA (Shino-Test Corporation, customized)28-day mortality
 van Zoelen [41]2007BelgiumProspective111ELISA (non-commercial)Hospital mortality
 Karlsson [42]2008FinlandProspective257ELISA (Shino-Test Corporation)ICU and hospital mortality
 Huang [43]2011ChinaProspective131ELISA (Shino-Test Corporation)Not specified
 Ueno [44]2011JapanProspective60ELISA (non-commercial)Not specified
 Narvaez-Rivera [45]2012MexicoProspective30ELISA (IBL International)28-day mortality
 Charoensup [46]2014ThailandProspective77ELISA (IBL International)1-month mortality
 Ravetti [47]2015BrazilProspective75ELISA (IBL International)28-day and ICU mortality
 Lee [48]2016KoreaProspective212ELISA (IBL International)28-day, ICU, and Hospital mortality
 Nobre [49]2016BrazilProspective62ELISA (IBL International)28-day and ICU mortality
Total number of patients = 1121  
sRAGE
 Bopp [50]2008GermanyProspective37ELISA (R&D Systems)28-day mortality
 Narvaez-Rivera [45]2012MexicoProspective30ELISA (R&D Systems)28-day mortality
 Brodska [51]2013Czech RepublicProspective54ELISA (R&D Systems)28-day mortality
 Hamasaki [52]2014BrazilProspective73Multiplex immunoassay (EMD Millipore)Not specified
Total number of patients = 194  
sTREM-1
 Gibot [53]2005FranceProspective63Immunoblotting (R&D Systems)28-day mortality
 Giamarellos-Bourboulis [54]2006GreeceProspective90ELISA (R&D Systems, customized)28-day mortality
 Phua [55]2008SingaporeProspective93Immunoblotting (R&D Systems)28-day mortality
 Suarez-Santamaria [56]2010SpainProspective253ELISA (R&D Systems, customized)7-day, 28-day, hospital, 6-months, and 1-year mortality
 Zhang [57]2011ChinaProspective52ELISA (R&D Systems)28-day mortality
 Su [58]2012ChinaProspective160ELISA (R&D Systems)28-day mortality
 Li [59]2014ChinaProspective102ELISA (R&D Systems)28-day mortality
 Bayram [60]2015TurkeyProspective74ELISA (R&D Systems)Not specified
 Ravetti [47]2015BrazilProspective75ELISA (R&D Systems)28-day and ICU mortality
 Charles [61]2016FranceProspective190ELISA (R&D Systems)14-day and ICU mortality
 Brenner [62]2017GermanyRetrospective120ELISA (R&D Systems)90-day mortality
Total number of patients = 1272  
suPAR
 Giamarellos-Bourboulis [63]2012GreeceProspective1914ELISA (ViroGates)28-day mortality
 Gustafsson [64]2012SwedenProspective49ELISA (ViroGates)90-day mortality
 Hoenigl [65]2013AustriaProspective132ELISA (ViroGates)28-day mortality
 Suberviola [66]2013SpainProspective137ELISA (ViroGates)ICU and hospital mortality
 Donadello [67]2014BelgiumProspective258ELISA (ViroGates)28-day and ICU mortality
 Khater [68]2016EgyptProspective80ELISA (R&D Systems)30-day mortality
 Liu [69]2016ChinaProspective137ELISA (ViroGates)28-day mortality
 Shan [70]2016ChinaProspective142ELISA (commercial, not specified)90-day mortality
 Tsirigotis [71]2016GreeceProspective105ELISA (ViroGates)28-day and ICU mortality
 Zeng [72]2016ChinaProspective126ELISA (USCN Life Science)28-day mortality
Total number of patients = 3080  
  1. ELISA enzyme-linked immunosorbent assay, ICU intensive care unit