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Table 4 White blood cells, procalcitonin and cytokine levels

From: IgM-enriched immunoglobulins (Pentaglobin) may improve the microcirculation in sepsis: a pilot randomized trial

 Baseline24 h72 hp (Friedman test)
White blood cell count (n/mmc)
 Pentaglobin (n = 10)9070 [5560–18,660]10,710 [6260–13,790]10,100 [7388–11,720]0.763
 Placebo (n = 9)12,000 [6145–23,300]12,560 [8185–25,090]12,990 [7275–26,220]0.569
Procalcitonin (ng/mL)
 Pentaglobin (n = 10)14.4 [3.4–48.6]14.6 [4.8, 28.8]7.1 [3.2–14.9]*0.026
 Placebo (n = 9)20.0 [4.5–95.1]19.7 [4.6–79.9]5.2 [2.4–33]**< 0.001
Interleukin-1 BETA (pg/mL)
 Pentaglobin (n = 10)5.3 [4–12.8]4.5 [4–6.7]4 [4–5.6]0.057
 Placebo (n = 9)4 [4–5.6]4 [4, 5]4 [4–5.8]0.376
Tumour necrosis factor alpha (pg/mL)
 Pentaglobin (n = 10)32 [20–84]18 [14–38]16 [12–28]0.078
 Placebo (n = 9)30 [24–77]39 [25–51]#19 [16–42]0.010
Interleukin-6 (pg/mL)
 Pentaglobin (n = 10)350 [104–1418]166 [61–781]151 [41–296]*0.030
 Placebo (n = 9)212 [52–971]98 [36–217]69 [21–141]0.154
Interleukin-8 (pg/mL)
 Pentaglobin (n = 10)138 [52–1268]74 [29–177]75 [49–108]0.262
 Placebo (n = 9)146 [66–302]62 [32–79]57 [45–115]0.278
Interleukin-10 (pg/mL)
 Pentaglobin (n = 10)30 [10–118]9 [5–15]*8 [6–13]**0.003
 Placebo (n = 9)20 [8–71]19 [6–29]10 [6–13]0.685
  1. Data are expressed as median [1st–3rd quartile]
  2. p < 0.05, **p < 0.01 versus baseline, Friedman test with Dunn’s test for multiple comparisons