Table 1 General characteristics
From: Diastolic shock index and clinical outcomes in patients with septic shock
Preliminary Cohort (n = 337) | Andromeda-Shock (n = 424) | |
|---|---|---|
General characteristics | ||
Age, years | 64 (51 to 74) | 66 (52 to 76) |
Male sex, n (%) | 188 (55.8) | 226 (53.3) |
Weight, Kg | 68 (59 to 76) | 70 (59 to 80) |
APACHE II | 16 (13 to 22) | 21 (17 to 28) |
SOFA day-1 | 9 (7 to 12) | 10 (7 to 12) |
Charlson Comorbidity Index | 4 (2 to 5) | 3 (1 to 5) |
Chronic hypertension, n (%) | 73 (39.2) | 176 (41.5) |
Source of Infection | ||
Lung | 120 (35.6) | 128 (30.2) |
Genitourinary | 60 (17.8) | 87 (20.5) |
Abdominal | 110 (32.6) | 149 (35.1) |
Other | 47 (13.9) | 60 (14.2) |
Delay time antibiotics, hours | 2 (− 2 to 5) | 2 (1 to 2) |
Time from first fluid resuscitation load up to vasopressor start, hours | 2 (0 to 3) | – |
Time from hypotension up to vasopressor start, hours | 3 (1 to 4) | – |
Time from septic shock diagnosis up to randomization, min | – | 81 (0 to 180) |
At vasopressor start | ||
SAP | 92 (83 to 106) | 100 (85 to 113) |
DAP | 45 (40 to 51) | 52 (45 to 60) |
MAP | 63 (56 to 69) | 66 (60 to 76) |
HR | 104 (87 to 121) | 103 (87 to 120) |
PP | 46 (35 to 59) | 45 (35 to 58) |
DSI | 2.28 (1.83 to 2.74) | 1.97 (1.58 to 2.48) |
SvO2, %, n | 71.7 (63.8 to 78.2), 196 | 73.0 (65.0 to 79.0), 401 |
Pv-aCO2, mmHg, n | 5.0 (3.7 to 7.0), 195 | 7.0 (5.0 to 10.0), 398 |
CVP at VPs, mmHg, n | 7 (4 to 12), 69 | 9 (6 to 13), 393 |
Lactate (initial), mmol/L, n | 2.7 (1.6 to 4.9), 337 | 3.5 (2.7 to 5.4), 424 |
Fluids/VP/RRT | ||
Volume of resuscitation fluids up to start of VP, mL | 1200 (400 to 2000) | 2000 (1200 to 2800) |
Volume of resuscitation fluids up to start of VP, mL/kg | 16.3 (5.7 to 30.0) | 27.8 (18.8 to 41.7) |
Volume of resuscitation fluids up to 8 h, mL | 1050 (1000 to 2500) | 1000 (0 to 2000) |
Net fluid balance | ||
At 24 h | 2700 (1200 to 4500) | 1940 (900 to to 3350) |
Norepinephrine max. dose, µg/kg/min | 0.26 (0.13 to 0.48) | 0.26 (0.11 to 0.45) |
Acute RRT | 94 (27.9) | 72 (17.0) |
Clinical outcomes | ||
ICU LOS | 9 (4 to 16) | 6 (3 to 12) |
Hospital LOS | 14 (6 to 29) | 13 (6 to 26) |
Mechanical ventilation-free days | 20 (0 to 27) | 16 (0 to 26) |
RRT-free days | 28 (6 to 28) | 28 (2 to 28) |
Mortality 28-day, n (%) | 129 (38.3) | 166 (39.2) |
Mortality 90-day, n (%) | 145 (43.0) | 186 (43.9) |