Beneficial effect modification on survival outcome of sepsis between ART-123 and polymyxin B‑immobilised haemoperfusion: a nationwide Japanese registry study

Annals of Intensive Care

Table 3 Adjusted hazard ratios of product terms between ART-123 and PMX-HP and related therapeutic variables

	Adjusted hazard ratio	95% confidence interval	P value
(a) Overall
ART-123 × PMX-HP	0.667	0.462–0.961	0.030
ART-123	0.774	0.639–0.937	0.009
PMX-HP	0.872	0.699–1.086	0.222
(b) Patients who required vasopressors
ART-123 × PMX-HP	0.637	0.439–0.925	0.018
ART-123	0.790	0.649–0.960	0.018
PMX-HP	0.889	0.710–1.112	0.301

PMX-HP polymyxin B‑immobilised haemoperfusion
The adjusted hazard ratio, 95% confidence interval, and P values indicate those calculated after the product term was introduced into the Cox regression model shown in Table 2 or 4