Table 2 Pharmacokinetic/pharmacodynamic parameters observed

Total administered dose (mg)

1900 [1000–3250]

Dose administered by body weight on D1 (mg/kg)

25 [15.6–31.8]

Time [end of infusion−C_max measurement] (min)

30 [10–55]

C_max D1 (mg/L)

55.2 [12.2–165.7]

C_max D1 ≥ 64 mg/L

38 (38.8)

C_max D1 ≥ 80 mg/L

18 (18.4)

C_max/MIC on D1

23.1 [1–169]

C_max/MIC ≥ 8 on D1

87 (88.8)

C_max/MIC ≥ 10 on D1

86 (87.8)

C_min D2 ≥ 2.5 mg/L^a

49 (59.8)