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Table 4 Comparison of static and dynamic liver parameters

From: Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)

 

Group A

Group C

pa,b

LiMAx (μg/kg/h)

71 (37–88)

438 (330–456)

< 0.001b

Lactate (mmol/L)

27 (24–30)

12 (9–14)

0.001a

INR

2.1 (1.5–2.7)

1.3 (1.3–1.4)

0.017a

Total bilirubin (mmol/L)

2.8 (1.5–5.6)

1.6 (0.6–2.2)

0.209a

Platelet counts (/nL)

60 (46–83)

312 (177–462)

0.017a

AST (IU/L)

28 (24–56)

59 (43–74)

0.097a

ALT (IU/L)

13 (12–39)

52 (33–94)

0.053a

GGT (IU/L)

67 (59–76)

202 (84–485)

0.051a

ALP (IU/L)

105 (83–152)

271 (143–381)

0.017a

MELD score

18 (16–36)

14 (11–23)

0.201b

  1. Data are presented as median and interquartile range (25th to 75th percentile)
  2. LiMAx: maximum liver function capacity; INR: international normalized ratio; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gamma-glutamyl transferase; ALP: alkaline phosphatase; MELD: model for end-stage liver disease
  3. aIndependent t test
  4. bMann–Whitney U test