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Table 4 Comparison of static and dynamic liver parameters

From: Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)

  Group A Group C pa,b
LiMAx (μg/kg/h) 71 (37–88) 438 (330–456) < 0.001b
Lactate (mmol/L) 27 (24–30) 12 (9–14) 0.001a
INR 2.1 (1.5–2.7) 1.3 (1.3–1.4) 0.017a
Total bilirubin (mmol/L) 2.8 (1.5–5.6) 1.6 (0.6–2.2) 0.209a
Platelet counts (/nL) 60 (46–83) 312 (177–462) 0.017a
AST (IU/L) 28 (24–56) 59 (43–74) 0.097a
ALT (IU/L) 13 (12–39) 52 (33–94) 0.053a
GGT (IU/L) 67 (59–76) 202 (84–485) 0.051a
ALP (IU/L) 105 (83–152) 271 (143–381) 0.017a
MELD score 18 (16–36) 14 (11–23) 0.201b
  1. Data are presented as median and interquartile range (25th to 75th percentile)
  2. LiMAx: maximum liver function capacity; INR: international normalized ratio; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gamma-glutamyl transferase; ALP: alkaline phosphatase; MELD: model for end-stage liver disease
  3. aIndependent t test
  4. bMann–Whitney U test