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Annals of Intensive Care

Table 1 Respiratory and hemodynamic parameters observed early in the course of protective mechanical ventilation in 22 COVID-19 ARDS patients

From: Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study

Ventilator settings

 VT set at 6 mL/kg PBW (mL)

412 [356–425]

 RR (/min)

33 [28.5–35]

 PEEP (cmH2O)

16 [15–17]

 FiO2 (%)

45 [40–58]

Respiratory mechanics

 Pplateau (cmH2O)

27 [25–28]

 PEEPtot (cmH2O)

16.5 [16–18]

 DP (cmH2O)

9.5 [9–11.75]

 Crs (mL/cmH2O)

39.5 [33.1–44.7]

 EELV (mL)

2100 [1721–2434]

Gas exchanges

 PaCO2 (mmHg)

55 [44–62]

 PaO2/FiO2

198 [167–298]

 DAaO2 (mmHg)

136 [102–209]

 ETCO2 (mmHg)

38 [33–45]

 VR

2.9 [2.2–3.4]

 VD/VT (%)

75 [69–80.5]

 VO2 (mL/min)

280 [226–327]

 VCO2 (mL/min)

210 [175–222]

Hemodynamic support

 Catecholamine support n (%)

8 (36%)

  1. VT tidal volume, PBW predicted body weight, RR respiratory rate, Pplateau plateau pressure, PEEPtot total PEEP measured during a prolonged expiratory pause, DP driving pressure, Crs respiratory system compliance, EELV end-expiratory lung volume, DAaO2 alveolo-arterial difference in O2 partial pressures, ETCO2 end-tidal expired CO2, VR ventilatory ratio, VD/VT physiological dead space, VO2 O2 total body uptake, VCO2 CO2 total body production
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