|
Original study arm
|
CRT Normal at 2 h (n = 184)
|
P
|
|---|
|
CRT
|
Lactate
|
|---|
|
Number of patients
|
102 (55)
|
82 (45)
| |
|
Age (years)
|
62 [46–72]
|
65 [49–74]
|
0.23
|
|
Sex
|
Female 49 (48)
|
Female 39 (48)
|
0.90
|
|
Male 53 (52)
|
Male 43 (52)
|
|
APACHE II score
|
20 [14–26]
|
19 [16–24]
|
0.96
|
|
SOFA score
|
9 [7–11]
|
9 [7–11]
|
0.63
|
|
Charlson Index
|
3 [1–5]
|
3 [1–5]
|
0.76
|
|
Sepsis origin n (%)
|
Urinary 17 (17)
|
Urinary 20 (24)
|
0.36
|
|
Pulmonary 37 (36)
|
Pulmonary 18 (22)
|
|
Abdominal 33 (33)
|
Abdominal 31 (37)
|
|
Other 14 (14)
|
Other 14 (17)
|
|
MAP (mmHg)
|
70 [65–83]
|
67 [62–75]
|
0.01
|
|
CVP (mmHg)
|
9 [6–13]
|
9 [5–14]
|
0.70
|
|
Pre-protocol fluids (ml)
|
2000 [1238–2850]
|
2050 [1500–2957]
|
0.15
|
|
NE dose (mcg/kg/min)
|
0.18 [0.1–0.31]
|
0.15 [0.1–0.3]
|
0.60
|
|
Baseline lactate (mmol/L)
|
3.3 [2.6–4.4]
|
3.2 [2.7–4.3]
|
0.73
|
|
Baseline CRT (s)
|
4 [2–5]
|
3 [2–4]
|
0.15
|
|
Baseline mottling score
|
0 [0–1]
|
0 [0–1]
|
0.60
|
|
Baseline ScvO2 (%)
|
74 [68–79]
|
71 [62–80]
|
0.40
|
|
Baseline dCO2(v-a)
|
7 [4–9]
|
7 [5–10]
|
0.70
|
|
Fluid bolus 0–8 h (ml)
|
500 [0–1500]
|
1000 [500–2000]
|
0.004
|
|
Fluid balance 8 h (ml)
|
1090 [319–2000]
|
1360 [559–2401]
|
0.038
|
|
Vasopressor test
|
19 (19)
|
35 (43)
|
0.001
|
|
Inodilator test
|
3 (3)
|
13 (16)
|
0.003
|
|
Resuscitative interventions
|
1.25 [0.5–3]
|
3 [1.8–4.2]
|
0.001
|
|
SOFA 24 h
|
7 [4–10]
|
8 [5–11]
|
0.11
|
|
dSOFA 0-24 h
|
2 [0–4]
|
1 [−1–3]
|
0.004
|
|
RRT
|
11 (11)
|
16 (19)
|
0.1
|
|
MV
|
66 (65)
|
57 (70)
|
0.50
|
|
ICU length of stay (days)
|
6 [3–12]
|
6 [3–11]
|
0.60
|
|
28-day mortality
|
23 (23)
|
33 (40)
|
0.009
|
- Data are presented as median [IQR 25–75] or count (percentage)
- CRT capillary refill time, APACHE II Acute Physiology And Chronic Health Evaluation II, SOFA Sequential organ failure Assessment score, ICU intensive care unit, MAP mean arterial pressure, CVP central venous pressure, NE norepinephrine, ScvO2 central venous oxygen saturation, Delta pCO2(v-a) difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure, dSOFA delta SOFA, RRT renal replacement therapy, MV mechanical ventilation
