Table 2 Clinical and interventions comparison between CRT responders at T2, according to study group
Original study arm | CRT Normal at 2 h (n = 184) | P | |
|---|---|---|---|
CRT | Lactate | ||
Number of patients | 102 (55) | 82 (45) | |
Age (years) | 62 [46–72] | 65 [49–74] | 0.23 |
Sex | Female 49 (48) | Female 39 (48) | 0.90 |
Male 53 (52) | Male 43 (52) | ||
APACHE II score | 20 [14–26] | 19 [16–24] | 0.96 |
SOFA score | 9 [7–11] | 9 [7–11] | 0.63 |
Charlson Index | 3 [1–5] | 3 [1–5] | 0.76 |
Sepsis origin n (%) | Urinary 17 (17) | Urinary 20 (24) | 0.36 |
Pulmonary 37 (36) | Pulmonary 18 (22) | ||
Abdominal 33 (33) | Abdominal 31 (37) | ||
Other 14 (14) | Other 14 (17) | ||
MAP (mmHg) | 70 [65–83] | 67 [62–75] | 0.01 |
CVP (mmHg) | 9 [6–13] | 9 [5–14] | 0.70 |
Pre-protocol fluids (ml) | 2000 [1238–2850] | 2050 [1500–2957] | 0.15 |
NE dose (mcg/kg/min) | 0.18 [0.1–0.31] | 0.15 [0.1–0.3] | 0.60 |
Baseline lactate (mmol/L) | 3.3 [2.6–4.4] | 3.2 [2.7–4.3] | 0.73 |
Baseline CRT (s) | 4 [2–5] | 3 [2–4] | 0.15 |
Baseline mottling score | 0 [0–1] | 0 [0–1] | 0.60 |
Baseline ScvO2 (%) | 74 [68–79] | 71 [62–80] | 0.40 |
Baseline dCO2(v-a) | 7 [4–9] | 7 [5–10] | 0.70 |
Fluid bolus 0–8 h (ml) | 500 [0–1500] | 1000 [500–2000] | 0.004 |
Fluid balance 8 h (ml) | 1090 [319–2000] | 1360 [559–2401] | 0.038 |
Vasopressor test | 19 (19) | 35 (43) | 0.001 |
Inodilator test | 3 (3) | 13 (16) | 0.003 |
Resuscitative interventions | 1.25 [0.5–3] | 3 [1.8–4.2] | 0.001 |
SOFA 24 h | 7 [4–10] | 8 [5–11] | 0.11 |
dSOFA 0-24 h | 2 [0–4] | 1 [−1–3] | 0.004 |
RRT | 11 (11) | 16 (19) | 0.1 |
MV | 66 (65) | 57 (70) | 0.50 |
ICU length of stay (days) | 6 [3–12] | 6 [3–11] | 0.60 |
28-day mortality | 23 (23) | 33 (40) | 0.009 |