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Table 2 Clinical and interventions comparison between CRT responders at T2, according to study group

From: A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study

Original study arm CRT Normal at 2 h (n = 184) P
CRT Lactate
Number of patients 102 (55) 82 (45)  
Age (years) 62 [46–72] 65 [49–74] 0.23
Sex Female 49 (48) Female 39 (48) 0.90
Male 53 (52) Male 43 (52)
APACHE II score 20 [14–26] 19 [16–24] 0.96
SOFA score 9 [7–11] 9 [7–11] 0.63
Charlson Index 3 [1–5] 3 [1–5] 0.76
Sepsis origin n (%) Urinary 17 (17) Urinary 20 (24) 0.36
Pulmonary 37 (36) Pulmonary 18 (22)
Abdominal 33 (33) Abdominal 31 (37)
Other 14 (14) Other 14 (17)
MAP (mmHg) 70 [65–83] 67 [62–75] 0.01
CVP (mmHg) 9 [6–13] 9 [5–14] 0.70
Pre-protocol fluids (ml) 2000 [1238–2850] 2050 [1500–2957] 0.15
NE dose (mcg/kg/min) 0.18 [0.1–0.31] 0.15 [0.1–0.3] 0.60
Baseline lactate (mmol/L) 3.3 [2.6–4.4] 3.2 [2.7–4.3] 0.73
Baseline CRT (s) 4 [2–5] 3 [2–4] 0.15
Baseline mottling score 0 [0–1] 0 [0–1] 0.60
Baseline ScvO2 (%) 74 [68–79] 71 [62–80] 0.40
Baseline dCO2(v-a) 7 [4–9] 7 [5–10] 0.70
Fluid bolus 0–8 h (ml) 500 [0–1500] 1000 [500–2000] 0.004
Fluid balance 8 h (ml) 1090 [319–2000] 1360 [559–2401] 0.038
Vasopressor test 19 (19) 35 (43) 0.001
Inodilator test 3 (3) 13 (16) 0.003
Resuscitative interventions 1.25 [0.5–3] 3 [1.8–4.2] 0.001
SOFA 24 h 7 [4–10] 8 [5–11] 0.11
dSOFA 0-24 h 2 [0–4] 1 [−1–3] 0.004
RRT 11 (11) 16 (19) 0.1
MV 66 (65) 57 (70) 0.50
ICU length of stay (days) 6 [3–12] 6 [3–11] 0.60
28-day mortality 23 (23) 33 (40) 0.009
  1. Data are presented as median [IQR 25–75] or count (percentage)
  2. CRT capillary refill time, APACHE II Acute Physiology And Chronic Health Evaluation II, SOFA Sequential organ failure Assessment score, ICU intensive care unit, MAP mean arterial pressure, CVP central venous pressure, NE norepinephrine, ScvO2 central venous oxygen saturation, Delta pCO2(v-a) difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure, dSOFA delta SOFA, RRT renal replacement therapy, MV mechanical ventilation