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Table 1 Main characteristics, comorbidities, biological data, microbiological investigations performed within the first 48 h of ICU admission and outcomes of 92 critically ill COVID-19 patients

From: Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU

  Critically ill patients with SARS-CoV-2 pneumonia
n = 92
Age, years 61 [55–70]
Male, n (%) 73 (79)
Baseline SOFA 4 [3–7]
Baseline SAPS II 31 [21–40]
Main comorbidities, n (%)
 Obesity (body mass index ≥ 30 kg/m2) 38 (41)
 Hypertension 59 (64)
 Diabetes mellitus 35 (38)
 Cardio-vascular diseases 9 (10)
 Atrial fibrillation 3 (3)
 Cerebro-vascular diseases 8 (9)
 Venous thrombo-embolism 5 (5)
 Chronic respiratory diseasesa 18 (20)
 Chronic renal failure 7 (8)
 Immunocompromised statusb 9 (10)
Before ICU admission
 Antibiotic therapy before (> 12 h) ICU admission, n (%) 39 (42)
 Number of days between the first symptom and ICU admission 8.5 [7–12]
 Number of days between hospitalization and ICU admission 1 [0–4]
 Hospitalization in the wards for 48 h or more before ICU admission, n (%) 30 (33)
Biological data at ICU admission
 Leukocytes count, 103/mm3 9.0 [6.8–12.2]
 Lymphocytes count, 103/mm3 0.8 [0.6–1.1]
 Platelets count, 103/mm3 226 [183–303]
 C-reactive protein, mg/L 175 [131–232]
 Procalcitonin, ng/mL 0.9 [0.3–2.2]
 Fibrinogen, g/L 7.7 [6.1–8.8]
Microbiological investigations performed during the first 48 h of ICU admission
 Blood cultures 80 (87)
 Legionella pneumophila urinary antigen test 88 (96)
 Streptococcus pneumoniae urinary antigen test 88 (96)
 Culture of respiratory tract secretions sample 67 (73)
 Multiplex PCR Panel RP2 plus (nasopharyngeal swab) 26 (28)
 Multiplex PCR Panel Pneumonia Plus (respiratory tract secretions) 30 (33)
 Influenza A and B specific PCR 13 (14)
 Culture of respiratory tract secretions sample or multiplex PCR 82 (89)
Outcomes in ICU
 Invasive mechanical ventilation 83 (90)
 Prone positioning 55 (60)
 Vasopressor support 57 (62)
 Renal replacement therapy 22 (24)
  ICU mortality 45 (49)
  1. Continuous variables are reported as median [Interquartile range] and categorical variables are reported as numbers (percentages)
  2. SOFA Sequential Organ Failure Assessment, SAPSII Simplified Acute Physiology Score II
  3. aIncluding chronic obstructive pulmonary disease (n = 6) or/and obstructive sleep apnea (n = 12) or/and asthma (n = 4)
  4. bIncluding chronic lymphocytic leukemia (n = 2), follicular or Hodgkin lymphoma (n = 2), liver transplantation (n = 1), long-term corticosteroid therapy (> 0.5 mg/kg for more than 3 months) (n = 3) or azathioprine (n = 1) administration