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Table 6 Main antidotes for cardiovascular drugs

From: Management of pharmaceutical and recreational drug poisoning

Antidote Toxin Indication Availability Comments
Atropine Negative chronotropic effects Bradycardia
QT prolongation
Immediate Expert opinion
Hypertonic sodium bicarbonate Membrane-stabilizing effects QRS ≥ 120 ms and MAP ≤ 65 mmHg Immediate Expert opinion
Calcium salts Calcium-channel blockers HR ≤ 60 bpm
MAP ≤ 65 mmHg
Immediate Expert opinion
Catecholamine Polyvalent Shock Immediate Grade 2
Digoxin antibody Fab fragments Digoxin   < 2 h Grade 2
Glucagon Beta-blockers Bradycardia < 2 h Expert opinion
Isoprenaline Beta-blockers (sotalol)
Negative chronotropic effects: calcium-channel blockers
QT prolongation
Torsades de pointes
Bradycardia
Immediate Expert opinion
Insulin–glucose Calcium-channel blockers
Beta-blockers
Bradycardia
MAP ≤ 65 mmHg
Immediate Expert opinion
  1. FC heart rate, MAP mean arterial pressure, SID supposed ingested dose