Table 1 Baseline characteristics of the study population
CRT targeted group | Lactate targeted group | |
|---|---|---|
N° | 21 | 21 |
Age (years) | 51 [45–75] | 66 [55–75] |
Female | 48 (10) | 66 (14) |
APACHE score | 23 [15–30] | 23 [14–34] |
SOFA score | 11 [8–14] | 12 [9–14] |
Septic Source | Abdominal: 62 (13) | Abdominal 52: (11) |
Other: 14 (3) | Other: 10 (2) | |
Respiratory: 14 (3) | Respiratory: 14 (3) | |
Urinary: 10 (2) | Urinary: 24 (5) | |
Surgical Source | 57 (12) | 62 (13) |
Time to antibiotics (min) | 60 [45–120] | 60 [30–60] |
Fluids Pre-randomization (ml) | 1550[1000–3000] | 2500 [1250–3175] |
MV at inclusion | 95 (21) | 81 (17) |
MAP (mmHg) | 71 [66–77] | 69 [61–78] |
CVP (mmHg) | 8 [5–12] | 8 [6–10] |
Cardiac Index (l/m/m2) | 3.1 [2.2–3.5] | 2.8 [1.9–3.9] |
Norepinephrine dose (mcg/kg/min) | 0.23 [0.14–0.54] | 0.29 [0.16–0.4] |
Lactate (mmol/L) | 3 [2.8–5.5] | 4 [3–7.6] |
CRT (s) | 5 [3–6.5] | 5 [3–6.5] |
ScvO2 (%) | 69 [65–78] | 70 [59–79] |
Delta pCO2(v-a) | 8 [4–13] | 7 [5–11] |
P(cv-a)CO2/Da-vO2 ratio | 2 [1–2.5] | 1.3 [1.1–2.8] |
L/P ratio | 8.1 [4–13.9] | 9 [4.7–14] |
StO2 (%) | 78 [66–82] | 78 [70–83] |
PDR-ICGa (%) | 18 [10–21.8] | 12 [10–15.4] |
MFIa | 1.75 [1–2.5] | 2.6 [2.5–3] |