Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome

Annals of Intensive Care

Table 1 Clinical characteristics of ten patients with Coronavirus 19 severe acute respiratory distress syndrome

Variables
Age (years)	60 (52–72)
Female gender	3 (30%)
Body mass index (kg/m²)	28.2 (22.0–37.4)
Comorbidities
Dyslipidemia	2 (20%)
Current smoker	2 (20%)
Arterial hypertension	5 (50%)
Diabetes mellitus	5 (50%)
Atrial fibrillation	0
Heart failure	0
Previous stroke	0
COPD	1 (10%)
Cirrhosis	0
Dialysis	1 (10%)
Previous stroke	0
Standard treatments
Anticoagulant	0
Antiplatelet therapy	0
ACE inhibitors or ARB	5 (50%)
Organ failure at admission
Charlson comorbidity index	2 (0–2)
SAPS-II	36 (32–46)
SOFA score	6 (3–7)
PaO₂/FiO₂	112 (92–144)
Neuromuscular-blocking agent use	7 (70%)
Shock	1 (10%)

Values are expressed as median (interquartile range)
C-ARDS COVID-19 ARDS patients, ARDS: acute respiratory distress syndrome, COPD chronic obstructive pulmonary disease, ACE angiotensin-converting enzyme, ARB angiotensin receptors blockers, SAPS II Simplified Acute Physiology Score II, SOFA score Sequential Organ Failure Assessment, PaO₂ arterial oxygen tension, FiO₂ fraction of inspired oxygen