Table 2 Ventilation, arterial blood gases, renal and hemodynamic parameters during the study period
ECCO2R | Analysis of variance p | |||||
|---|---|---|---|---|---|---|
VT 6 mL/kg (n = 18) | VT 6 mL/kg (n = 18) | VT 4 mL/kg (n = 18) | VT 4 mL/kg (n = 16) | VT 6 mL/kg (n = 17) | ||
Day 0 | Day 1 | |||||
Ventilation variable | ||||||
VT (mL/kg PBW) | 6.06 (6–6.35) | 6.11 (6–6.30) | 4.04 (4–4.19)* | 4.13 (4–4.28)* | 6.09 (5.83–6.48) | < 0.001 |
VM (L/min) | 10.7 (10.1–12.2) | 10.8 (10.1–12.2) | 7 (6.4–8.4)* | 7.8 (6.5–8.7)* | 11 (10.1–12.2) | < 0.001 |
RR (breaths/min) | 28 (25–30) | 28 (25–30) | 29 (25–30) | 30 (27.5–32) | 28 (26–30) | 0.7 |
PEEP (cm H2O) | 11.5 (9.3–14.8) | 11.5 (10–15) | 12 (10–14.8) | 13 (9.5–15.3) | 13(10–16) | 0.9 |
Pplat (cm H2O) | 25.5 (24–28) | 26 (22.3–28.8) | 21.5 (20–25.8)* | 22.5 (19.8–25.3)* | 24 (22–28) | 0.04 |
Driving pressure (cm H2O) | 11.5 (10–17.8) | 11 (10–17) | 9 (8–10) | 8.5 (6–11.5) | 11 (9–16) | 0.2 |
PaO2/FiO2 (mmHg) | 108.5 (96.5–136.3) | 109.5 (85.3–143) | 116 (83.3–161) | 113.5 (81.9–142) | 112 (69–131) | 0.9 |
Blood gases | ||||||
PaO2 (mmHg) | 79.9 (68.3–88.7) | 70.7 (64.7–87.8) | 81.8 (70.7–110.4) | 72.8 (68.3–95.1) | 65.6 (58.3–79.4)* | 0.4 |
PaCO2 (mmHg) | 43.1 (38.2–57.9) | 37.7 (33.5–48.3)* | 50 (45.1–58.6)* | 52.5 (44.2–64)* | 39 (35.7–46.9) | 0.001 |
Patients with PaCO2 > 50 mmHg at baseline (n, %) | 7 (39) | |||||
FiO2 (%) | 70 (60–88.8) | 70 (60–90) | 80 (61.3–100) | 85 (57.5–100) | 75 (50–100) | 0.8 |
pH | 7.38 (7.34–7.42) | 7.42 (7.38–7.44)* | 7.31 (7.26–7.35)* | 7.31 (7.27–7.33)* | 7.41 (7.36–7.44) | < 0.001 |
Lactate (mmol/l) | 1.2 (0.9–1.4) | 1.2 (1–1.7) | 1.2 (0.9–1.4) | 1.2 (1–1.5) | 1.2 (1–1.6) | 0.6 |
HCO3-(mmol/l) | 23.6 (22.9–27.9) | 22.6 (21.6–27.3) | 23.4 (22.8–27.3) | 25.2 (22.2–30) | 24.9 (20.9–26.8) | 0.8 |
Renal function | ||||||
Diuresis (ml) | 860 (325–1191) | 1700 (351–2050) | 0.06 | |||
Creatinine (μmol/l) | 72 (56–137) | 81 (58–176) | 0.9 | |||
Patients with CRRT (n, %) | 4 (22) | 4 (22) | 0.9 | |||
Hemodynamic | ||||||
Mean arterial pressure (mmHg) | 75 (70–80) | 87 (79–95)* | 84 (73–97)* | 80 (73–87) | 86 (68–87)* | 0.4 |
Heart rate (beats/min) | 84 (65–100) | 75 (56–91)* | 95 (57–100)* | 86 (71–95) | 76 (70–95) | 0.8 |
Patients on norepinephrine, n (%) | 4 (22.2) | 4 (22.2) | 2 (22.2) | 4 (25) | 5 (29.4) | |
Norepinephrine dose (μg/kg/min) | 0.25 (0.20–0.27) | 0.21 (0.12–0.44) | 0.11 (0.29–0.43) | 0.24 (0.41–0.54) | 0.19 (0.38–0.44) | 0.6 |
Patients on dobutamine | 1 (5.6) | 1 (5.6) | 1 (5.6) | 1 (6.3) | 1 (5.9) | |
Total fluid resuscitation (ml) | 250 (0–750) | |||||
Prone positioning during protocol (n, %) | 6 (33) | |||||