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Table 2 Ventilation, arterial blood gases, renal and hemodynamic parameters during the study period

From: Ultraprotective ventilation allowed by extracorporeal CO2 removal improves the right ventricular function in acute respiratory distress syndrome patients: a quasi-experimental pilot study

  ECCO2R Analysis of variance p
VT 6 mL/kg (n = 18) VT 6 mL/kg (n = 18) VT 4 mL/kg (n = 18) VT 4 mL/kg (n = 16) VT 6 mL/kg (n = 17)
Day 0 Day 1
Ventilation variable
 VT (mL/kg PBW) 6.06 (6–6.35) 6.11 (6–6.30) 4.04 (4–4.19)* 4.13 (4–4.28)* 6.09 (5.83–6.48)  < 0.001
 VM (L/min) 10.7 (10.1–12.2) 10.8 (10.1–12.2) 7 (6.4–8.4)* 7.8 (6.5–8.7)* 11 (10.1–12.2)  < 0.001
 RR (breaths/min) 28 (25–30) 28 (25–30) 29 (25–30) 30 (27.5–32) 28 (26–30) 0.7
 PEEP (cm H2O) 11.5 (9.3–14.8) 11.5 (10–15) 12 (10–14.8) 13 (9.5–15.3) 13(10–16) 0.9
 Pplat (cm H2O) 25.5 (24–28) 26 (22.3–28.8) 21.5 (20–25.8)* 22.5 (19.8–25.3)* 24 (22–28) 0.04
 Driving pressure (cm H2O) 11.5 (10–17.8) 11 (10–17) 9 (8–10) 8.5 (6–11.5) 11 (9–16) 0.2
 PaO2/FiO2 (mmHg) 108.5 (96.5–136.3) 109.5 (85.3–143) 116 (83.3–161) 113.5 (81.9–142) 112 (69–131) 0.9
Blood gases
 PaO2 (mmHg) 79.9 (68.3–88.7) 70.7 (64.7–87.8) 81.8 (70.7–110.4) 72.8 (68.3–95.1) 65.6 (58.3–79.4)* 0.4
 PaCO2 (mmHg) 43.1 (38.2–57.9) 37.7 (33.5–48.3)* 50 (45.1–58.6)* 52.5 (44.2–64)* 39 (35.7–46.9) 0.001
 Patients with PaCO2 > 50 mmHg at baseline (n, %) 7 (39)  
 FiO2 (%) 70 (60–88.8) 70 (60–90) 80 (61.3–100) 85 (57.5–100) 75 (50–100) 0.8
 pH 7.38 (7.34–7.42) 7.42 (7.38–7.44)* 7.31 (7.26–7.35)* 7.31 (7.27–7.33)* 7.41 (7.36–7.44)  < 0.001
 Lactate (mmol/l) 1.2 (0.9–1.4) 1.2 (1–1.7) 1.2 (0.9–1.4) 1.2 (1–1.5) 1.2 (1–1.6) 0.6
 HCO3-(mmol/l) 23.6 (22.9–27.9) 22.6 (21.6–27.3) 23.4 (22.8–27.3) 25.2 (22.2–30) 24.9 (20.9–26.8) 0.8
Renal function
 Diuresis (ml) 860 (325–1191) 1700 (351–2050) 0.06
 Creatinine (μmol/l) 72 (56–137) 81 (58–176) 0.9
 Patients with CRRT (n, %) 4 (22) 4 (22) 0.9
Hemodynamic
 Mean arterial pressure (mmHg) 75 (70–80) 87 (79–95)* 84 (73–97)* 80 (73–87) 86 (68–87)* 0.4
 Heart rate (beats/min) 84 (65–100) 75 (56–91)* 95 (57–100)* 86 (71–95) 76 (70–95) 0.8
 Patients on norepinephrine, n (%) 4 (22.2) 4 (22.2) 2 (22.2) 4 (25) 5 (29.4)  
 Norepinephrine dose (μg/kg/min) 0.25 (0.20–0.27) 0.21 (0.12–0.44) 0.11 (0.29–0.43) 0.24 (0.41–0.54) 0.19 (0.38–0.44) 0.6
 Patients on dobutamine 1 (5.6) 1 (5.6) 1 (5.6) 1 (6.3) 1 (5.9)  
 Total fluid resuscitation (ml) 250 (0–750)  
Prone positioning during protocol (n, %) 6 (33)  
  1. Values presented as median and IQR, interquartile range (25–75%)
  2. PBW predicted body weight, ECCO2R extracorporeal CO2 removal, VT, tidal volume, VM minute ventilation, RR respiratory rate, PEEP positive end-expiratory pressure, Pplat plateau pressure, PaO2 partial alveolar oxygen pressure, FiO2 fraction of inspired oxygen, PaCO2 partial alveolar carbon dioxide pressure, HCO3 bicarbonate, CRRT continuous renal replacement therapy
  3. *p < 0.05 vs baseline