Proceedings of Réanimation 2020, the French Intensive Care Society International Congress

Annals of Intensive Care

Table 1 Most frequent drugs responsable for hyperammonaemia

Substances	n	IC 0.25	Serious adverse events, n	Serious adverse events, %	Fatal adverse events, n	Fatal adverse events, %
Valproic acid	1260	6.86	768	61	54	4
Fluorouracil	221	4.27	213	96	20	9
Topiramate	96	4.33	65	68	0	0
Oxaliplatin	74	2.53	68	92	12	16
Asparaginase	71	5.09	50	70	6	8
Levofolinic acid	51	5.44	51	100	6	12
Paracetamol	48	0.95	38	79	16	33
Tacrolimus	37	1.80	36	97	25	68
Levetiracetam	35	2.21	25	71	3	9
Carbamazepine	35	1.48	24	69	0	0
Bevacizumab	34	1.43	34	100	3	9
Methotrexate	33	0.43	31	94	11	33