Table 1 Characteristics of infected patients with or without sepsis defined by Sepsis-3 or eSOFA criteria
Characteristic | eSOFA (−) n = 1143 | eSOFA (+) n = 573 | Sepsis-3 (−) n = 781 | Sepsis-3 (+) n = 935 |
|---|---|---|---|---|
Median age (IQR) | 79 (62–84) | 82 (75–87)** | 78 (57–84) | 81 (74–86)‡ |
Gender, n (%) | ||||
Male | 642 (56.2) | 346 (60.4) | 414 (53.0) | 574 (61.4)‡ |
BMI, kg/m2, median (IQR) | 23 (20–26) | 23 (20–26) | 24 (21–26) | 23 (20–26)† |
Bedridden, n (%) | 580 (50.7) | 310 (54.1)** | 388 (49.7) | 502 (53.7)‡ |
Type of hospital admission, n (%) | ||||
Medical | 1047 (91.6) | 506 (88.3)* | 691 (88.5) | 862 (92.2)‡ |
Elective surgery | 85 (7.4) | 43 (7.5) | 75 (9.6) | 53 (5.7)‡ |
Emergency surgery | 11 (1.0) | 24 (4.2)** | 15 (1.9) | 20 (2.1) |
McCabe and Jackson classification, n (%) | ||||
Nonfatal | 814 (71.2) | 394 (68.8) | 524 (67.1) | 684 (73.2)‡ |
Ultimately fatal | 169 (14.8) | 120 (20.9)** | 112 (14.3) | 177 (18.9)† |
Rapidly fatal | 21 (1.8) | 24 (4.2)** | 22 (2.8) | 23 (2.5) |
Charlson Comorbidity Index, median (IQR) | 1 (1–3) | 2 (1–3)** | 1 (0–3) | 2 (1–3)‡ |
Comorbidities (Charlson), n (%) | ||||
Cancera | 174 (15.2) | 131 (22.9)** | 133 (17.0) | 172 (18.4) |
Congestive heart failure | 12 (1.0) | 28 (4.9)** | 9 (1.2) | 31 (3.3)‡ |
Chronic pulmonary disease | 237 (20.7) | 148 (25.8)* | 150 (19.2) | 235 (25.1)‡ |
Diabetes | 328 (28.7) | 126 (22.0)** | 206 (26.4) | 248 (26.5) |
Liver disease | 15 (1.3) | 17 (3.0)* | 13 (1.7) | 19 (2.0) |
Renal disease | 46 (4.0) | 31 (5.4) | 10 (1.3) | 67 (7.2)‡ |
Chronic organ dysfunction (APACHE II), n (%) | ||||
Cardiovascular | 11 (1.0) | 26 (4.5)** | 8 (1.0) | 29 (3.1)‡ |
Respiratory | 37 (3.2) | 70 (12.2)** | 42 (5.4) | 65 (7.0) |
Liver | 15 (1.3) | 17 (3.0)* | 13 (1.7) | 19 (2.0) |
Renal | 34 (3.0) | 21 (3.7) | 10 (1.3) | 45 (4.8)‡ |
Immunosuppression | 94 (8.2) | 57 (9.9) | 62 (7.9) | 89 (9.5) |
Site of infection, n (%) | ||||
Pneumonia | 660 (57.7) | 374 (65.3)** | 432 (55.3) | 602 (64.4)‡ |
Urogenital tract infection | 90 (7.9) | 11 (1.9)** | 68 (8.7) | 33 (3.5)‡ |
Intra-abdominal infection | 105 (9.2) | 72 (12.6)* | 81 (10.4) | 96 (10.3) |
Skin/soft tissue infection | 25 (2.2) | 3 (0.5)* | 24 (3.1) | 4 (0.4)‡ |
Septicemia/bacteremia | 18 (1.6) | 13 (2.3) | 18 (2.3) | 13 (1.4) |
Two or more infections | 61 (5.3) | 66 (11.5)** | 55 (7.0) | 72 (7.7) |
Outcomes | ||||
Median hospital LOS (IQR) | 17 (9–30) | 23 (11–40)* | 17 (9–29) | 20 (11–38)† |
Required ICU admission, n (%) | 33 (2.9) | 218 (38.1)** | 16 (2.0) | 235 (25.1)‡ |
Death, n (%) | 86 (7.5) | 267 (46.6)** | 54 (6.9) | 299 (32.0)‡ |