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Table 1 Characteristics of infected patients with or without sepsis defined by Sepsis-3 or eSOFA criteria

From: External validity of Adult Sepsis Event’s simplified eSOFA criteria: a retrospective analysis of patients with confirmed infection in China

CharacteristiceSOFA (−)
n = 1143
eSOFA (+)
n = 573
Sepsis-3 (−)
n = 781
Sepsis-3 (+)
n = 935
Median age (IQR)79 (62–84)82 (75–87)**78 (57–84)81 (74–86)
Gender, n (%)    
 Male642 (56.2)346 (60.4)414 (53.0)574 (61.4)
BMI, kg/m2, median (IQR)23 (20–26)23 (20–26)24 (21–26)23 (20–26)
Bedridden, n (%)580 (50.7)310 (54.1)**388 (49.7)502 (53.7)
Type of hospital admission, n (%)    
 Medical1047 (91.6)506 (88.3)*691 (88.5)862 (92.2)
 Elective surgery85 (7.4)43 (7.5)75 (9.6)53 (5.7)
 Emergency surgery11 (1.0)24 (4.2)**15 (1.9)20 (2.1)
McCabe and Jackson classification, n (%)    
 Nonfatal814 (71.2)394 (68.8)524 (67.1)684 (73.2)
 Ultimately fatal169 (14.8)120 (20.9)**112 (14.3)177 (18.9)
 Rapidly fatal21 (1.8)24 (4.2)**22 (2.8)23 (2.5)
Charlson Comorbidity Index, median (IQR)1 (1–3)2 (1–3)**1 (0–3)2 (1–3)
Comorbidities (Charlson), n (%)    
 Cancera174 (15.2)131 (22.9)**133 (17.0)172 (18.4)
 Congestive heart failure12 (1.0)28 (4.9)**9 (1.2)31 (3.3)
 Chronic pulmonary disease237 (20.7)148 (25.8)*150 (19.2)235 (25.1)
 Diabetes328 (28.7)126 (22.0)**206 (26.4)248 (26.5)
 Liver disease15 (1.3)17 (3.0)*13 (1.7)19 (2.0)
 Renal disease46 (4.0)31 (5.4)10 (1.3)67 (7.2)
Chronic organ dysfunction (APACHE II), n (%)    
 Cardiovascular11 (1.0)26 (4.5)**8 (1.0)29 (3.1)‡
 Respiratory37 (3.2)70 (12.2)**42 (5.4)65 (7.0)
 Liver15 (1.3)17 (3.0)*13 (1.7)19 (2.0)
 Renal34 (3.0)21 (3.7)10 (1.3)45 (4.8)
 Immunosuppression94 (8.2)57 (9.9)62 (7.9)89 (9.5)
Site of infection, n (%)    
 Pneumonia660 (57.7)374 (65.3)**432 (55.3)602 (64.4)
 Urogenital tract infection90 (7.9)11 (1.9)**68 (8.7)33 (3.5)
 Intra-abdominal infection105 (9.2)72 (12.6)*81 (10.4)96 (10.3)
 Skin/soft tissue infection25 (2.2)3 (0.5)*24 (3.1)4 (0.4)
 Septicemia/bacteremia18 (1.6)13 (2.3)18 (2.3)13 (1.4)
 Two or more infections61 (5.3)66 (11.5)**55 (7.0)72 (7.7)
Outcomes    
 Median hospital LOS (IQR)17 (9–30)23 (11–40)*17 (9–29)20 (11–38)
 Required ICU admission, n (%)33 (2.9)218 (38.1)**16 (2.0)235 (25.1)
 Death, n (%)86 (7.5)267 (46.6)**54 (6.9)299 (32.0)
  1. IQR interquartile range, BMI body mass index, LOS length of stay
  2. *p < 0.05, **p < 0.01, compared with eSOFA (−); p < 0.05, p < 0.01, compared with Sepsis-3 (−)
  3. aCancer includes solid tumor with or without metastases, leukemia, and lymphoma