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Table 3 Cox proportional hazard regression analysis for 30-day mortality

From: Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis

CharacteristicsUnivariateMultivariate
HR (95% CI)p valueHR (95% CI)p value
Age, per 1 year increment1.003 (0.991–1.014)0.631.006 (0.993–1.019)0.38
Sex
 Female1 [Reference] 1 [Reference] 
 Male1.113 (0.743–1.667)0.601.251 (0.798–1.959)0.33
HbA1c, per 1 increment1.045 (0.935–1.167)0.440.926 (0.804–1.066)0.28
Cerebrovascular disease
 No1 [Reference] 1 [Reference] 
 Yes0.602 (0.317–1.146)0.120.432 (0.218–0.856)0.01
Chronic pulmonary disease
 No1 [Reference] 1 [Reference] 
 Yes0.506 (0.328–0.779)< 0.010.506 (0.320–0.800)< 0.01
APACHE II, per 1 increment1.056 (1.027–1.086)< 0.011.040 (1.008–1.073)< 0.01
Lactate 0-h, per 1 mg/dL increment1.010 (1.005–1.014)< 0.011.009 (1.003–1.015)< 0.01
Hemoglobin, per 1 g/dL increment0.967 (0.818–2.672)0.400.983 (0.906–1.066)0.68
Creatinine, per 1 mg/dL increment1.048 (0.993–1.105)0.091.028 (0.949–1.113)0.50
Hypoglycemia episode (< 40 mg/dL)
 No1 [Reference] 1 [Reference] 
 Yes2.098 (0.293–15.009)0.461.660 (0.209–13.203)0.63
Mean day 1 glucose, per 1 mg/dL increment1.004 (1.000–1.008)0.041.014 (1.005–1.024)< 0.01
Peak day 1 glucose, per 1 mg/dL increment1.002 (1.000–1.004)0.080.993 (0.987–0.998)0.01
CoV, cut-off point 30%
 Low1 [Reference] 1 [Reference] 
 High1.683 (1.191–2.378)< 0.012.593 (1.494–4.499)< 0.01
  1. HR hazard ratio, CI confidence interval, HbA1c hemoglobin A1c, APACHE II acute physiology and chronic health evaluation II, CoV coefficient of variation