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Table 3 Determinants associated with ICU-acquired pneumonia using sub-distribution hazard ratio in univariate and multivariate analysis

From: Increased susceptibility to intensive care unit-acquired pneumonia in severe COVID-19 patients: a multicentre retrospective cohort study

Variables group

Univariate

Multivariate

SHR

95% CI

p

SHR

95% CI

p

Group

 Bacterial pneumonia

Ref

Ref

Ref

Ref

Ref

Ref

 COVID-19

1.52

1.17–1.98

0.001

2.18

1.2–3.98

0.011

 Viral pneumonia

0.8

0.46–1.42

0.46

0.76

0.43–1.36

0.35

 Male gender

1.67

1.23–2.27

0.001

1.55

1.14–2.12

0.005

 Obesity

1.25

0.96–1.63

0.094

   

 Immunosuppression

0.68

0.5–0.93

0.02

   

 Admission SAPS2, per point

0.99

0.99–1

0.06

   

 Admission SOFA, per point

0.97

0.95–1.01

0.15

   

 COPD

0.65

0.45–0.97

0.032

   

 Cancer

0.73

0.52–1.04

0.081

   

 Prone positioning

1.03

1–1.07

0.075

   

 Vasopressors

1.42

0.97–2.08

0.073

   

 Blood transfusion

1.21

0.93–1.57

0.15

   

  Conventional respiratory device

0.39

0.21–0.73

0.003

   

 Antimicrobial treatment

0.46

0.24–0.9

0.023

   

 ARDS

1.61

1.39–2.37

 < 0.001

1.84

1.25–2.72

0.002

 Duration of MV prior to VAP, days

1.02

1.02–1.04

 < 0.001

1.027

1.01–1.04

 < 0.001

  1. SAPS2, Simplified Acute Physiology Score 2; COPD, chronic obstructive pulmonary disease; ARDS, acute respiratory distress syndrome; MV, mechanical ventilation. All covariates were analysed at baseline except for mechanical ventilation that was evaluated as time-dependent covariate