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Annals of Intensive Care

Table 2 Multivariable Cox regression models with P-PENK and P-NGAL at baseline for prediction of AKIcrea within 48 h

From: Predictive value of plasma proenkephalin and neutrophil gelatinase-associated lipocalin in acute kidney injury and mortality in cardiogenic shock

 

Hazard ratio

95% CI

p value

p value for addition*

c-statistic with PENK/NGAL

c-statistic without PENK/NGAL

Model 1

      

 P-PENK > 84.8 pmol/mL at baseline

2.2

1.1–4.4

0.03

0.02

0.689

0.677

 Prior use of diuretics

2.4

1.2–4.9

0.01

   

  Arterial pH

0.7

0.6–0.9

0.01

   

 Prior use of ACEI or ARB

0.4

0.2–0.8

0.01

   

Model 2

      

 P-NGAL > 104 ng/mL at baseline

2.8

1.2–6.5

0.01

0.007

0.684

0.634

 Arterial pH

0.9

0.7–1.1

0.14

   
  1. ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blocker, NGAL neutrophil gelatinase-associated lipocalin, PENK proenkephalin
  2. *2 log-likelihood test for additive value of P-PENK/P-NGAL in the model
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