Predictors of fluid responsiveness in critically ill patients mechanically ventilated at low tidal volumes: systematic review and meta-analysis

Annals of Intensive Care

Table 3 Operative performance of predictors of fluid responsiveness

Predictor of fluid responsiveness	Sensibility	Specificity	AUC	Threshold (%)	DOR	I² (%)
First group
PPV	0.74 (0.66–0.81)	0.77 (0.70–0.83)	0.82	10	11.70 (6.73–20.37)	56
Tidal volume challenge	0.90 (0.76–0.97)	0.87 (0.31–0.99)	0.92	3	82.95 (12.37–556.12)	8
SVV	0.83 (0.75–0.88)	0.85 (0.78–0.90)	0.90	12	28.82 (12.43–66.84)	63
Second group
ΔIVC	0.77 (0.65–0.86)	0.87 (0.70–0.95)	0.86	16	24.13 (9.71–59.67)	0
Third group
Mini-fluid challenge	0.84 (0.76–0.90)	0.76 (0.68–0.83)	0.84	1	15.57 (8.02–30.25)	9
PLR	0.83 (0.61–0.94)	0.80 (0.68–0.88)	0.84	13	31.65 (4.16–240.93)	74
EEOT	0.82 (0.73–0.89)	0.89 (0.82–0.94)	0.92	5	39.35 (14.80–104.60)	51

Values are expressed as pooled value (95% confidence interval). AUC, area under curve; I², inconsistency; DOR, diagnostic odds ratio; EEOT, end expiratory occlusion; PLR, passive leg raising; PPV, pulse pressure variation; SVV, stroke volume variability. Values are expressed as pooled data (95% confidence interval)