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Table 1 Characteristics of patients at ICU admission

From: Poor outcome associated with mucormycosis in critically ill hematological patients: results of a multicenter study

N (%) or Median (IQR)

All

n = 26

Survivors in ICU

n = 6

Non survivors in ICU

n = 20

P value

Demographics

    

 Age (years)

38 [26–57]

28 [34–35]

44 [28–58]

0.26

 Male gender

13 (50)

3 (50)

10 (50)

1.00

Hematological malignancy

   

0.78

 Acute leukemia

13 (50)

3 (50)

10 (50)

 

  - ALL

7

2

5

 

  - AML

6

1

5

 

 Lymphoma

5 (20)

1 (17)

4 (20)

 

  - Hodgkin

1

0

1

 

  - Non-Hodgkin

4

1

3

 

 Aplastic anemia

4 (15)

1 (17)

3 (15)

 

 Othera

4 (15)

1 (17)

3 (15)

 

Status of HM

   

0.41

 Recently diagnosed

8 (31)

3 (50)

5 (25)

 

 At least partial response

11 (42)

1 (17)

10 (50)

 

 Progression

5 (19)

2 (33)

3 (15)

 

 Unknown

2 (8)

0

2 (10)

 

Previous treatments

    

 Allogeneic SCT

9 (35)

0

9 (45)

0.12

 Steroids during the last 3 months

16 (62)

5 (83)

11 (55)

0.52

 Antifungal prophylaxis

7 (27)

3 (50)

4 (22)

0.44

Reason for ICU admission

   

0.15

 Acute respiratory failure

14 (53)

2 (33)

12 (60)

 

 Shock

5 (19)

3 (50)

2 (10)

 

 Perioperative management

3 (12)

0

3 (15)

 

 Coma

1 (4)

0

1 (5)

 

 Acute kidney injury

1 (4)

0

1 (5)

 

 Otherb

2 (8)

1 (17)

1 (5)

 

Biological tests

    

 Creatinine (µmol/L)

84 [49–119]

76 [56–90]

86 [45–123]

0.46

 Albumin (g/L)

26 [23–31]

28 [24–30]

25 [23–30]

0.85

 Bilirubin (µmol/L)

25.9 [15.0–43.0]

25.1 [17.1–30.8]

25.9 [12.7–46.5]

1.00

 Leukocytes (G/L)

0.22 [0.10–2.60]

0.58 [0.21–1.06]

0.20 [0.10–4.30]

0.85

 Hemoglobin (g/dL)

8.4 [7.9–9.1]

8.0 [7.1–9.5]

8.5 [8.0–9.0]

0.50

 Platelets (G/L)

25 [13–42]

17 [6–30]

26 [14–41]

0.24

 Prothrombin (%)

70 [50–76]

56 [48–73]

71 [58–75]

0.55

SOFA score

7 [5–8]

6 [5–6]

7 [5.5–9.5]

0.18

Treatments in the ICU

    

 Mechanical ventilation

21 (81)

1 (17)

20 (100)

 < 0.001

 Vasopressors

18 (69)

3 (50)

15 (75)

0.51

 Renal replacement therapy

9 (35)

0

9 (45)

0.12

  1. ICU intensive care unit, ALL acute lymphoblastic leukemia, AML acute myeloid leukemia, HM hematological malignancy, SCT stem cell transplantation, SOFA score Sepsis-related Organ Failure Assessment
  2. aMyelodysplastic syndrome, chronic myeloid leukemia, hairy cell leukemia and hemophagocytic syndrome
  3. bIncluding diabetic ketoacidosis and monitoring