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Table 1 Demographic data and clinical characteristics

From: Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study

  Total population (n = 191) Responders (n = 96) Non responders (n = 95) P
Age—yr 66 [59–72] 65 [59–72] 68 [59–72] 0.25
Sex—male—no (%) 152 (79.6) 75 (78) 77 (81) 0.72
BMI 28 [26–31] 28 [25–31] 28 [26–31] 0.35
SAPS II score 38 [30–45] 38[30–46] 38[30–44] 0.81
SOFA score 5 [3–7] 4 [3–6] 5 [3–7] 0.31
Hypertension—no (%) 104 (54.5) 50 (52) 54 (57) 0.56
Chronic ischemic heart disease—no (%) 20 (10.5) 8 (8) 12 (13) 0.36
Chronic kidney disease—no (%) 12 (6.3) 5 (5.2) 7 (7.4) 0.57
Diabetes—no (%) 46 (24.1) 22 (22.9) 24 (25.3) 0.74
Chronic liver disease (MELD > 10)—n (%) 3 (1.6) 1 (1) 2 (2.1) 0.62
COPD—no (%) 14 (7.3) 8 (8.3) 6 (6.3) 0.39
HFNO before intubation—no (%)—183 20 (10.9) 13 (13.5) 7 (7.4) 0.24
CPAP/NIV before intubation—no (%) 127 (70.4) 60 (62.5) 67 (70.5) 0.20
PaO2/FiO2 before intubation—mmHg 94 [76–112] 90 [70–113] 96 [80–110] 0.50
Tidal volume set—ml/kg IBW 7.2 [6.6–7.8] 7.3[6.5–8.1] 7.1[6.6–7.6] 0.48
PEEP set—cmH2O 12 [10–14] 12 [10–15] 12 [10–14] 0.80
Highest Pplata—cmH2O 25 [23–28] 25 [22–28] 26 [24–29] 0.04
Lowest CRS supinea—ml/cmH2O 35 [29–41] 37 [30–43] 33 [27–40] 0.005
Lowest PaO2/FiO2a—mmHg 90 [69—113] 89 [67—114] 90 [70—110] 0.87
 Class 3—P/F200—300 (%) 0 (0) 0 (0) 0 (0)  
 Class 2—P/F 100—200 (%) 72 (38.8) 40 (41.7) 32 (33.7)  
 Class 1—P/F < 100 (%) 119 (62.3) 56 (58.3) 63 (66.3)  
Duration of CPAP/NIV trial before intubation (n = 127) (n = 60) (n = 67) 0.23
  < 12 h—no (%) 26 (20.5) 8 (13.3) 18 (26.9)  
 12—24 h—no (%) 31 (24.4) 16 (26.7) 15 (22.4)  
 24—48 h—no (%) 22 (17.3) 13 (21.7) 9 (13.4)  
  > 48 h—no (%) 48 (37.8) 23 (38.3) 25 (37.3)  
  1. Data expressed as median [IQR] or counts (% in group). Comparisons were performed using Mann–Whitney U test or Chi-square test. Significant P values are highlighted in bold
  2. BMI  body mass index, SAPS  simplified acute physiology score, SOFA  sequential organ failure assessment score, COPD  chronic obstructive pulmonary disease, CPAP  continuous positive airway pressure, MELD  model for end-stage liver disease, NIV  non-invasive ventilation, PaO2  arterial oxygen partial pressure, FiO2  inspired fraction of oxygen, IBW  Ideal Body Weight, PEEP  positive end expiratory pressure, Pplat  plateau pressure, CRS  respiratory system compliance, HFNO  high flow nasal oxygen, PP  prone position, DP  driving pressure
  3. aDuring the first 5 days of ICU stay